SYNTHESIS OF PHENANTHRIDIN-3-ONE DERIVATIVES - NONSTEROIDAL INHIBITORS OF STEROID 5-ALPHA-REDUCTASE

被引：21
作者：
MOOK, RA
LACKEY, K
BENNETT, C
机构：
[1] Glaxo Research Institute, Research Triangle Park, NC 27709, Five Moore Drive
来源：
TETRAHEDRON LETTERS | 1995年 / 36卷 / 23期
关键词：
D O I：
10.1016/0040-4039(95)00690-E
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A short and efficient six-step synthesis of novel phenanthridin-3-one derivatives is described. The synthesis of these derivatives is highlighted by the cyclization of a suitably placed ketone side chain with a thioiminium ion. The derivatives prepared were found to be inhibitors of human steroid 5-alpha reductase.
引用
收藏
页码：3969 / 3972
页数：4
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