THE MOLECULAR-BIOLOGY OF HEPATITIS-C VIRUS

被引：53
作者：
MATSUURA, Y
MIYAMURA, T
机构：
[1] Department of Virology II, National Institute of Health, Shinjuku-ku, Tokyo, 162
来源：
SEMINARS IN VIROLOGY | 1993年 / 4卷 / 05期
关键词：
NON-A; NON-B HEPATITIS; POLYMERASE CHAIN REACTION; FLAVI-VIRUSES OR PESTI-VIRUSES; NUCLEOTIDE SEQUENCES; HEPATOCELLULAR CARCINOMA;
D O I：
10.1006/smvy.1993.1026
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Hepatitis C virus (HCV) is one of the main causative agents for transfusion associated- and sporadic cases of non-A, non-B hepatitis throughout the world. HCV has a positive strand RNA of about 9400 nucleotides, as its genome, whose organization is similar to those of animal pestiviruses or human flaviviruses. In spite of the lack of the effective replication system in tissue culture cells, parts of the viral genome were expressed under the control of foreign promoters and the synthesized viral protein has been used for diagnostic assays. © 1993 Academic Press. All rights reserved.
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页码：297 / 304
页数：8
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