INFECTION OF GNOTOBIOTIC PIGS WITH AN ESCHERICHIA-COLI O157-H7 STRAIN ASSOCIATED WITH AN OUTBREAK OF HEMORRHAGIC COLITIS

被引：124

作者：

FRANCIS, DH ^{[1
]}

COLLINS, JE ^{[1
]}

DUIMSTRA, JR ^{[1
]}

机构：

[1] S DAKOTA STATE UNIV, DEPT VET SCI, BROOKINGS, SD 57007 USA

来源：

INFECTION AND IMMUNITY | 1986年 / 51卷 / 03期

关键词：

D O I：

10.1128/IAI.51.3.953-956.1986

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Gnotobiotic pigs inoculated with an Escherichia coli O157:H7 strain isolated from a human with hemorrhagic colitis developed anorexia, lethargy, and watery diarrhea. Bacteria diffusely colonized the cecum and colon surfaces and the crypt epithelium. At bacterial attachment sites, microvilli were effaced, and epithelial cells were irregularly shaped, rounded, or detached. Submucosa, lamina propria, and mesentery were markedly edematous and contained many inflammatory cells.

引用

页码：953 / 956

页数：4

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