CONFORMATIONAL-ANALYSIS AND ACTIVE-SITE MODELING OF ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS

被引：86

作者：

ANDREWS, PR ^{[1
]}

CARSON, JM ^{[1
]}

CASELLI, A ^{[1
]}

SPARK, MJ ^{[1
]}

WOODS, R ^{[1
]}

机构：

[1] INST DRUG TECHNOL LTD,PARKVILLE,VIC 3052,AUSTRALIA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1985年 / 28卷 / 03期

关键词：

D O I：

10.1021/jm00381a021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：393 / 399

页数：7

共 29 条

[1] CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTER - COMPUTER-BASED SEARCH, RETRIEVAL, ANALYSIS AND DISPLAY OF INFORMATION [J].

ALLEN, FH ;

BELLARD, S ;

BRICE, MD ;

CARTWRIGHT, BA ;

DOUBLEDAY, A ;

HIGGS, H ;

HUMMELINK, T ;

HUMMELINKPETERS, BG ;

KENNARD, O ;

MOTHERWELL, WDS ;

RODGERS, JR ;

WATSON, DG .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1979, 35 (OCT) :2331-2339

[2] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A KETOMETHYLENE ANALOG OF A TRIPEPTIDE INHIBITOR OF ANGIOTENSIN CONVERTING ENZYME [J].

ALMQUIST, RG ;

CHAO, WR ;

ELLIS, ME ;

JOHNSON, HL .

JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (12) :1392-1398

[3] STRUCTURE ACTIVITY RELATIONSHIPS OF CONVULSANT AND ANTI-CONVULSANT BARBITURATES - A COMPUTER-GRAPHIC-BASED PATTERN-RECOGNITION ANALYSIS [J].

ANDREWS, PR ;

MARK, LC ;

WINKLER, DA ;

JONES, GP .

JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (09) :1223-1229

[4] MOLECULAR-CONFORMATION AND BIOLOGICAL-ACTIVITY OF CENTRAL NERVOUS-SYSTEM ACTIVE-DRUGS [J].

ANDREWS, PR ;

LLOYD, EJ .

MEDICINAL RESEARCH REVIEWS, 1982, 2 (04) :355-393

[5]

[Anonymous], 1965, BIFAO, V63, P1

[6] NEW POTENT INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME [J].

ATTWOOD, MR ;

FRANCIS, RJ ;

HASSALL, CH ;

KROHN, A ;

LAWTON, G ;

NATOFF, IL ;

NIXON, JS ;

REDSHAW, S ;

THOMAS, WA .

FEBS LETTERS, 1984, 165 (02) :201-206

[7] ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS - IMPORTANCE OF THE AMIDE CARBONYL OF MERCAPTOACYL AMINO-ACIDS FOR HYDROGEN-BONDING TO THE ENZYME [J].

CONDON, ME ;

PETRILLO, EW ;

RYONO, DE ;

REID, JA ;

NEUBECK, R ;

PUAR, M ;

HEILKES, JE ;

SABO, EF ;

LOSEE, KA ;

CUSHMAN, DW ;

ONDETTI, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (03) :250-258

[8]

Cushman D W, 1980, Prog Med Chem, V17, P41, DOI 10.1016/S0079-6468(08)70157-7

[9] SQ-14,225 - 1-(D-3-MERCAPTO-2-METHYLPROPIONYL)-L-PROLINE [J].

FUJINAGA, M ;

JAMES, MNG .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1980, 36 (DEC) :3196-3199

[10] CALCULATION OF VAN DER WAALS INTERACTIONS AND HYDROGEN BONDING IN CRYSTALS [J].

GIGLIO, E .

NATURE, 1969, 222 (5191) :339-&

← 1 2 3 →