CHROMOSOME LOCALIZATION OF HUMAN ARH GENES, A RAS-RELATED GENE FAMILY

被引：40
作者：
CANNIZZARO, LA
MADAULE, P
HECHT, F
AXEL, R
CROCE, CM
HUEBNER, K
机构：
[1] COLUMBIA UNIV COLL PHYS & SURG,INST CANC RES,NEW YORK,NY 10032
[2] COLUMBIA UNIV COLL PHYS & SURG,HOWARD HUGHES MED INST,NEW YORK,NY 10032
[3] TEMPLE UNIV,HLTH SCI CTR,SCH MED,FELS INST CANC RES & MOLEC BIOL,PHILADELPHIA,PA 19140
来源：
GENOMICS | 1990年 / 6卷 / 02期
关键词：
D O I：
10.1016/0888-7543(90)90557-B
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The human ARH genes (previously called RHO) share several properties with the ras gene family. Three members of the ARH family, the H6, H9, and H12 genes, have been localized to human chromosomes 2, 5, and 3, respectively. Analysis of DNAs from a rodent-human somatic cell hybrid panel demonstrates linkage of H6 to chromosome region 2p12→2pter and H9 to region 5q33→5qter. In situ chromosome hybridization also showed that the primary site for H9 is in the 5q31→-qter region. The H12 gene was some-what difficult to localize using rodent-human hybrids because the probe detects a family of rodent genes as homologous to the human probe as is the human cognate gene. However, chromosome in situ hybridization revealed grains clustered in region 3p14→3p22 with a significant peak in band 3p21. We conclude that H6 is in 2p12→pter, H9 in 5q31→5qter, and H12 in 3p21. © 1990.
引用
收藏
页码：197 / 203
页数：7
相关论文
共 34 条
[1]   RAS GENES [J].
BARBACID, M .
ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :779-827
[2]   LOCALIZATION OF THE GENE FOR FAMILIAL ADENOMATOUS POLYPOSIS ON CHROMOSOME-5 [J].
BODMER, WF ;
BAILEY, CJ ;
BODMER, J ;
BUSSEY, HJR ;
ELLIS, A ;
GORMAN, P ;
LUCIBELLO, FC ;
MURDAY, VA ;
RIDER, SH ;
SCAMBLER, P ;
SHEER, D ;
SOLOMON, E ;
SPURR, NK .
NATURE, 1987, 328 (6131) :614-616
[3]  
CANNIZZARO LA, 1987, AM J HUM GENET, V41, P1
[4]   STRUCTURAL ALTERATION OF VIRAL HOMOLOG OF RECEPTOR PROTOONCOGENE FMS AT CARBOXYL TERMINUS [J].
COUSSENS, L ;
VANBEVEREN, C ;
SMITH, D ;
CHEN, E ;
MITCHELL, RL ;
ISACKE, CM ;
VERMA, IM ;
ULLRICH, A .
NATURE, 1986, 320 (6059) :277-280
[5]   MAPPING OF 4 DISTINCT BCR-RELATED LOCI TO CHROMOSOME REGION 22Q11 - ORDER OF BCR LOCI RELATIVE TO CHRONIC MYELOGENOUS LEUKEMIA AND ACUTE LYMPHOBLASTIC-LEUKEMIA BREAKPOINTS [J].
CROCE, CM ;
HUEBNER, K ;
ISOBE, M ;
FAINSTAIN, E ;
LIFSHITZ, B ;
SHTIVELMAN, E ;
CANAANI, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (20) :7174-7178
[6]   HUMAN C-MYC ONC GENE IS LOCATED ON THE REGION OF CHROMOSOME-8 THAT IS TRANSLOCATED IN BURKITT-LYMPHOMA CELLS [J].
DALLAFAVERA, R ;
BREGNI, M ;
ERIKSON, J ;
PATTERSON, D ;
GALLO, RC ;
CROCE, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (24) :7824-7827
[7]   PAPILLOMAVIRUS SEQUENCES INTEGRATE NEAR CELLULAR ONCOGENES IN SOME CERVICAL CARCINOMAS [J].
DURST, M ;
CROCE, CM ;
GISSMANN, L ;
SCHWARZ, E ;
HUEBNER, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (04) :1070-1074
[8]   TRANSLOCATION OF AN IMMUNOGLOBULIN-K LOCUS TO A REGION 3' OF AN UNREARRANGED C-MYC ONCOGENE ENHANCES C-MYC TRANSCRIPTION [J].
ERIKSON, J ;
NISHIKURA, K ;
ARRUSHDI, A ;
FINAN, J ;
EMANUEL, B ;
LENOIR, G ;
NOWELL, PC ;
CROCE, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (24) :7581-7585
[9]   CHROMOSOMAL LOCALIZATION OF THE HUMAN C-FMS ONCOGENE [J].
GROFFEN, J ;
HEISTERKAMP, N ;
SPURR, N ;
DANA, S ;
WASMUTH, JJ ;
STEPHENSON, JR .
NUCLEIC ACIDS RESEARCH, 1983, 11 (18) :6331-6339
[10]   LOCALIZATION OF SINGLE COPY DNA-SEQUENCES ON G-BANDED HUMAN-CHROMOSOMES BY INSITU HYBRIDIZATION [J].
HARPER, ME ;
SAUNDERS, GF .
CHROMOSOMA, 1981, 83 (03) :431-439
1234