SYSTEMIC AND SUPRASPINAL, BUT NOT SPINAL, OPIATES SUPPRESS ALLODYNIA IN A RAT NEUROPATHIC PAIN MODEL

被引：134
作者：
LEE, YW
CHAPLAN, SR
YAKSH, TL
机构：
[1] UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
[2] YONSEI UNIV,COLL MED,DEPT ANESTHESIOL,SEOUL 120749,SOUTH KOREA
来源：
NEUROSCIENCE LETTERS | 1995年 / 199卷 / 02期
关键词：
SYSTEMIC; SPINAL; SUPRASPINAL; OPIATES; ALLODYNIA; NEUROPATHIC PAIN;
D O I：
10.1016/0304-3940(95)12034-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of intraperitoneal (IF), intracerebroventricular (ICV) and intrathecal (IT) opiates were studied in the rat neuropathic pain model of Kim and Chung. Dose dependent reduction of allodynia was observed after IP and ICV morphine, but not after IT morphine, IT or ICV c[D-pen2 D-pen5]enkephalin (DPDPE) (delta agonist), or IT or ICV U50488H (kappa agonist). The effects of ICV morphine were blocked by IP naloxone, but not by IT methysergide, phentolamine or 8-sulfophenyltheophylline. Catalepsy (immobility) was observed after IT, ICV and IT morphine but this was not reliably associated with a reduction of allodynia. IP and ICV morphine may thus reduce tactile allodynia via supraspinal, but not spinal, mu opioid receptors.
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收藏
页码：111 / 114
页数：4
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