ERYTHEMA FORMATION IN MAGNESIUM-DEFICIENT ALBINO-RATS - A NONINVASIVE MODEL FOR THE SCREENING OF ANTIINFLAMMATORY AGENTS AND ORAL MINERAL SUPPLEMENTS

被引：0

作者：

CLASSEN, CU

ABELE, C

SCHIMATSCHEK, HF

FRIEDBERG, KD

CLASSEN, HG

HAUBOLD, W

机构：

[1] UNIV HOHENHEIM,DEPT PHARMACOL & TOXICOL NUTR,W-7000 STUTTGART 70,GERMANY

[2] UNIV HOHENHEIM,DEPT INORGAN & ANALYT CHEM,W-7000 STUTTGART 70,GERMANY

[3] UNIV HEIDELBERG,FAK KLIN MED MANNHEIM,INST PHARMACOL & TOXICOL,W-6800 MANNHEIM 1,GERMANY

来源：

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1993年 / 43-1卷 / 06期

关键词：

CROMOGLYCATE; ERYTHEMA; MAGNESIUM; DEPLETION; MINERAL SUPPLEMENTS; OMEPRAZOLE; POLYETHYLENE GLYCOL 400;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The enteral bioavailability of magnesium firmly bound to a fire-proof inert SiO2-Al2O3 matrix (ground magnesia boats) was studied in magnesium-deficient albino Sprague-Dawley rats, with and without blocking gastric hydrochloric acid secretion with omeprazole. Magnesium was absorbed, although to a small degree, also at anacidity. Pronounced erythema, developing after only some days in hypomagnesemic hypercalcemic rats, are proposed as a non-invasive model for the screening of antiinflammatory substances. Using this model significant protective effects were proven for cromoglycate, polyenthylene glycol 400, and omeprazole; the latter, however, seems more likely to act via a magnesium-sparing mechanism.

引用

页码：672 / 675

页数：4