THE LEAKS AND SLIPS OF BIOENERGETIC MEMBRANES

被引：47
作者：
BROWN, GC
机构：
[1] Biochemistry/Molecular Biology Dept., University College London, London WC1E 6BT, Gower Street
来源：
FASEB JOURNAL | 1992年 / 6卷 / 11期
关键词：
PROTON PERMEABILITY; PROTON STOICHIOMETRY; MEMBRANE PERMEABILITY; BIOENERGETICS; MITOCHONDRIA;
D O I：
10.1096/fasebj.6.11.1644259
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bioenergetic membranes use proton gradients to transduce energy. However, when the proton gradient is large 1) there is a passive leak of protons (and other ions) across these membranes, and 2) some proton pumps may fail to pump protons (a phenomenon known as slip). Leaks and slips may be an unavoidable consequence of membrane structure and cause significant wastage of free energy, but they may also have functional roles beneficial to the organism.
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收藏
页码：2961 / 2965
页数：5
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