THYROTROPIN-RELEASING-HORMONE EXCITES SUBMUCOUS NEURONS IN GUINEA-PIG ILEUM

被引：9
作者：
ZAFIROV, DH [1 ]
COOKE, HJ [1 ]
WOOD, JD [1 ]
机构：
[1] OHIO STATE UNIV, COLL MED, DEPT PHYSIOL, 333 W 10TH AVE, COLUMBUS, OH 43210 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 204卷 / 01期
关键词：
ENTERIC NERVOUS SYSTEM; AUTONOMIC GANGLIA; ILEUM (GUINEA-PIG); THYROTROPIN-RELEASING HORMONE (TRH); INTESTINAL SECRETION; INTESTINAL MUCOSA; SYNAPTIC TRANSMISSION;
D O I：
10.1016/0014-2999(91)90843-F
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Actions of thyrotropin-releasing hormone (TRH) on submucous neurons of the guinea-pig ileum were examined with intracellular electrophysiological methods. TRH evoked excitatory responses in S/type 1 and AH/type 2 neurons. The responses consisted of slowly activating membrane depolarization, augmented excitability and an increase in input resistance that resulted from a decrease in potassium conductance. The results suggest a neuromodulatory/neurotransmitter function for TRH.
引用
收藏
页码：109 / 112
页数：4
相关论文
共 50 条
  • [31] Effect of selective phosphodiesterase inhibitors on synaptic transmission in the guinea-pig ileum
    Izzo, AA
    Mascolo, N
    Capasso, F
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 357 (06) : 677 - 681
  • [32] INTRAMURAL NEURONS IN THE URINARY-BLADDER OF THE GUINEA-PIG
    GABELLA, G
    CELL AND TISSUE RESEARCH, 1990, 261 (02) : 231 - 237
  • [33] CCKA and CCKB receptor subtypes both mediate the effects of CCK-8 on myenteric neurons in the guinea-pig ileum
    Schutte, IWM
    Akkermans, LMA
    Kroese, ABA
    JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1997, 67 (1-2): : 51 - 59
  • [34] ENHANCEMENT BY KW-5092, A NOVEL GASTROPROKINETIC AGENT, OF THE RELEASE OF ACETYLCHOLINE FROM ENTERIC NEURONS IN THE GUINEA-PIG ILEUM
    KISHIBAYASHI, N
    ISHII, A
    KARASAWA, A
    JAPANESE JOURNAL OF PHARMACOLOGY, 1994, 64 (04) : 289 - 295
  • [35] NEUROIMMUNE COMMUNICATION IN THE SUBMUCOUS PLEXUS OF GUINEA-PIG COLON AFTER SENSITIZATION TO MILK ANTIGEN
    FRIELING, T
    COOKE, HJ
    WOOD, JD
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1994, 267 (06): : G1087 - G1093
  • [36] ACTIONS OF 5-HYDROXYTRYPTAMINE ON MYENTERIC NEURONS IN GUINEA-PIG GASTRIC ANTRUM
    TACK, JF
    JANSSENS, J
    VANTRAPPEN, G
    WOOD, JD
    AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (06): : G838 - G846
  • [37] SPONTANEOUS TONE IN DIFFERENT TYPES OF LONGITUDINAL MUSCLE PREPARATIONS OF GUINEA-PIG ILEUM
    SUZUKI, N
    SHIBAYAMA, T
    MAMBO, T
    GOMI, Y
    JAPANESE JOURNAL OF PHARMACOLOGY, 1995, 69 (01) : 23 - 28
  • [38] Morphological and immunohistochemical identification of neurons and their targets in the guinea-pig duodenum
    Clerc, N
    Furness, JB
    Li, ZS
    Bornstein, JC
    Kunze, WAA
    NEUROSCIENCE, 1998, 86 (02) : 679 - 694
  • [39] CALRETININ-IMMUNOREACTIVE NEURONS AND THEIR PROJECTIONS IN THE GUINEA-PIG COLON
    MCCONALOGUE, K
    LOW, AM
    WILLIAMSON, S
    BORNSTEIN, JC
    FURNESS, JB
    CELL AND TISSUE RESEARCH, 1994, 276 (02) : 359 - 365
  • [40] OPIOID AGONIST AFFINITY IN THE GUINEA-PIG ILEUM AND MOUSE VAS-DEFERENS
    PORRECA, F
    LOPRESTI, D
    WARD, SJ
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 179 (1-2) : 129 - 139
12345