THYROTROPIN-RELEASING-HORMONE EXCITES SUBMUCOUS NEURONS IN GUINEA-PIG ILEUM

被引：9

作者：

ZAFIROV, DH ^{[1
]}

COOKE, HJ ^{[1
]}

WOOD, JD ^{[1
]}

机构：

[1] OHIO STATE UNIV, COLL MED, DEPT PHYSIOL, 333 W 10TH AVE, COLUMBUS, OH 43210 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 204卷 / 01期

关键词：

ENTERIC NERVOUS SYSTEM; AUTONOMIC GANGLIA; ILEUM (GUINEA-PIG); THYROTROPIN-RELEASING HORMONE (TRH); INTESTINAL SECRETION; INTESTINAL MUCOSA; SYNAPTIC TRANSMISSION;

D O I：

10.1016/0014-2999(91)90843-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Actions of thyrotropin-releasing hormone (TRH) on submucous neurons of the guinea-pig ileum were examined with intracellular electrophysiological methods. TRH evoked excitatory responses in S/type 1 and AH/type 2 neurons. The responses consisted of slowly activating membrane depolarization, augmented excitability and an increase in input resistance that resulted from a decrease in potassium conductance. The results suggest a neuromodulatory/neurotransmitter function for TRH.

引用

页码：109 / 112

页数：4

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