EXPRESSION OF SERUM IL-2, IL-2R, AND CD8 LEVELS DURING HYPOSENSITIZATION IN HOUSE-DUST-SENSITIVE ASTHMATICS

被引：14
作者：
TSAI, LC
TANG, RB
HUNG, MW
CHEN, HM
TSAI, SJ
机构：
[1] Clinical Immunology Laboratory, Departments of Medical Research and Pediatrics Verterans, General Hospital-Taipei, Taipei
来源：
JOURNAL OF ASTHMA | 1990年 / 27卷 / 05期
关键词：
D O I：
10.3109/02770909009073343
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
In this study, we used the enzyme-linked immunosorbent assay (ELISA) to evaluate the changes of serum interleukin-2 (IL-2), interleukin-2 receptor (IL-2R), and suppressor/cytotoxicity factor (CD8) in house dust-sensitive asthmatic children during hyposensitization. Patients before immunotherapy presented significantly higher serum levels of IL-2 and IL-2R than normal subjects (p < 0.001), but these levels became normal after three years of hyposensitization. No significant difference of serum CD8 level was noted between pretreated patients and normal controls. Although the serum CD8 level in treated patients also decreased after three years of immunotherapy, this decrease was not significant compared with the pretreated patients (p > 0.05). This study suggests that serum IL-2 and IL-2R markers might be helpful in analyzing allergic states associated with immune activation and in evaluating the therapeutic effects of hyposensitization. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
收藏
页码：307 / 313
页数：7
相关论文
共 20 条
  • [1] Miyamoto T., Oshima S., Ishizaki T., Sato S., Allergenic identity between the common flour mite (D. farinae) and house dust as a causative antigen in bronchial asthma, J Allergy, 42, pp. 14-17, (1968)
  • [2] Solomon W.R., Mathews K.P., Aerobiology and inhalant allergens, Allergy Principles and Practice, pp. 899-956, (1978)
  • [3] Tang R.B., Cheng H.N., Lin F.M., Chang Y.F., Chou S.N., Lin C.Y., Serum IgE, skin and radioallergosorbent tests for house dust and mites in asthmatic children, J Asthma, 23, pp. 245-249, (1988)
  • [4] Tsai L.C., Tang R.B., Hung M.W., Chen H.M., Hwang L.A., Correlation between serum IgE and specific IgE antibody titer to house dust mite in children with asthma, J Asthma, 25, pp. 7-13, (1988)
  • [5] Lockey R.F., Bukantz S.C., Diagnostic tests hyposensitization therapy asthma, Bronchial Asthma, Mechanisms and Therapeutics, pp. 613-637, (1976)
  • [6] Oppenheim J.J., Moore R., Gmelig-Meyling F., Togawa A., Wahl S., Mathieson B.J., Dougherty S., Carter C., Role of cytokine and endotoxin-induced monokines in lymphocyte proliferation, differentiation and immunoglobulin production, Macrophage Regulation of Immunity, pp. 379-398, (1980)
  • [7] Morgan D.A., Ruscetti F.W., Gallo R.C., Selective in vitro growth of T lymphocytes from normal human bone marrows, Science, 193, pp. 1007-1008, (1976)
  • [8] Smith K.A., T cell growth factor, Immunol Rev, 51, pp. 337-357, (1980)
  • [9] Robb R.J., Munck A., Smith K.A., T cell growth factor receptors. Quantitation, specificity and biological relevance, J Exp Med, 154, pp. 1455-1474, (1981)
  • [10] Mier J.W., Gallo R.C., Human T-lymphocyte growth factor (TCGF): Biochemical properties and interaction with and production normal and neoplastic human T cells, Lymphokines 6. Lym-phokines in Antibody and Cytotoxic Responses, pp. 137-158, (1982)
12