ASSIGNMENT OF 12 LOCI TO RAT CHROMOSOME-5 - EVIDENCE THAT THIS CHROMOSOME IS HOMOLOGOUS TO MOUSE CHROMOSOME-4 AND TO HUMAN CHROMOSOME-9 AND CHROMOSOME-1 (1P ARM)

被引：56

作者：

SZPIRER, C ^{[1
]}

RIVIERE, M ^{[1
]}

SZPIRER, J ^{[1
]}

GENET, M ^{[1
]}

DREZE, P ^{[1
]}

ISLAM, MQ ^{[1
]}

LEVAN, G ^{[1
]}

机构：

[1] GOTHENBURG UNIV,DEPT GENET,S-40033 GOTHENBURG,SWEDEN

来源：

GENOMICS | 1990年 / 6卷 / 04期

关键词：

D O I：

10.1016/0888-7543(90)90504-N

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Twelve loci have been assigned to rat chromosome 5: aldolase B (ALDOB), atrial natriuretic factor (ANF = pronatriodilatin, PND), D4RP1, DSI1, galactosyltransferase (GGTB2), glucose transporter (GLUT1), interferon α1 and related interferon α (INFA), interferon β (INFB), lymphocyte-specific protein-tyrosine kinase (LCK), oncogene MOS, α2U-globulin (major urinary protein, MUP), and orosomucoid (ORM, also called α1-acid glycoprotein, AGP). Among these, the interferon α and β genes map in the q22-23 region, which also contains a transformation suppressor gene (SAI1). The other loci reside outside this region. This study also indicated that the rat genome contains 2 LCK genes, unlike the human and murine genomes. These new assignments on rat chromosome 5 demonstrate that this chromosome is highly homologous to mouse chromosome 4 and carries synteny groups conserved on human chromosome 9 (interferon α and β, galactosyltransferase, orosomucoid, and aldolase B genes) and on the short arm of human chromosome 1 (MYCL, glucose transporter, protein kinase LCK, and atrial natriuretic factor genes). © 1990.

引用

页码：679 / 684

页数：6

共 38 条

[1] GENETICS AND EVOLUTION OF THE ACUTE PHASE PROTEINS IN MICE [J].