Human papillomavirus type 6 E7 protein is a substrate in vitro of protein kinase C

被引：11

作者：

Armstrong, DJ ^{[1
]}

Roman, A ^{[1
]}

机构：

[1] INDIANA UNIV, SCH MED, DEPT MICROBIOL & IMMUNOL, INDIANAPOLIS, IN 46202 USA

来源：

BIOCHEMICAL JOURNAL | 1995年 / 312卷

关键词：

D O I：

10.1042/bj3120667

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The E7 proteins of 'low-risk' and 'high-risk' human papillomaviruses (HPV) are phosphorylated by casein kinase II. In this study, we report that the 'low-risk' HPV 6 E7 protein, but not the 'high-risk' HPV 16 E7 protein, can be phosphorylated in vitro on threonine at amino acid position 7 by protein kinase C. This is the first example of a qualitative biochemical difference between the HPV 6 E7 and HPV 16 E7 proteins.

引用

页码：667 / 670

页数：4

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