LACTIC-ACID OLIGOMER MICROSPHERES CONTAINING HYDROPHILIC DRUGS

被引：77

作者：

WADA, R ^{[1
]}

HYON, SH ^{[1
]}

IKADA, Y ^{[1
]}

机构：

[1] KYOTO UNIV,MED POLYMERS & BIOMAT RES CTR,53 KAWAHARA CHO,SAKYO KU,KYOTO 606,JAPAN

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1990年 / 79卷 / 10期

关键词：

D O I：

10.1002/jps.2600791016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new method was developed for preparation of biodegradable lactic acid oligomer microspheres containing hydrophilic drugs. The microspheres were obtained by removal of solvent from an O/O (oil‐in‐oil) emulsion through evaporation. The solvent used for the dispersed phase solution was an acetonitrile:water mixture, while the continuous phase medium was cottonseed oil. Doxorubicin hydrochloride (ADR) and insulin were successfully entrapped in the microspheres with high trapping efficiencies of 80 to 90%, and their release profiles were not accompanied with the significant burst effect. The release rate of the drugs from the microspheres was greatly affected by the initial loading of the drugs and the molecular weight of the lactic acid oligomer. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：919 / 924

页数：6

共 11 条

[1] BECK LR, 1979, FERTIL STERIL, V31, P545
[2] A PHYSICOCHEMICAL STUDY OF THE MORPHOLOGY OF PROGESTERONE-LOADED POLY (D,L-LACTIDE) MICROSPHERES
BENOIT, JP
COURTEILLE, F
THIES, C
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1986, 29 (2-3) : 95 - 102
[3] JAMSHIDI K, 1984, THESIS KYOTO U JAPAN
[4] JUNI K, 1985, CHEM PHARM BULL, V33, P313
[5] KWONG A K, 1986, Journal of Controlled Release, V4, P47, DOI 10.1016/0168-3659(86)90033-7
[6] STUDIES ON MICROENCAPSULATION .7. MICROENCAPSULATION AND CONTROLLED RELEASE OF INSULIN FROM POLYLACTIC ACID MICROCAPSULES
LIN, SY
HO, LT
CHIOU, HL
[J]. BIOMATERIALS MEDICAL DEVICES AND ARTIFICIAL ORGANS, 1985, 13 (3-4): : 187 - 201
[7] MIYAMURA S, 1961, J ANTIBIOT B, V14, P251
[8] ANALYSIS OF INSULIN BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY .4. STABILITY OF INSULIN IN HYDROCHLORIC-ACID
OHTA, M
TOKUNAGA, H
KIMURA, T
YAMAHA, T
[J]. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1984, 104 (12): : 1309 - 1313
[9] WADA R, 1988, J BIOACT COMPAT POL, V3, P126
[10] WADA R, 1989, B I CHEM RES KYOTO U, V66, P241

← 1 2 →