SWITCH PEPTIDES - PH-INDUCED ALPHA-HELIX TO BETA-SHEET TRANSITIONS OF BIS-AMPHIPHILIC OLIGOPEPTIDES

被引：71
|
作者：
MUTTER, M
GASSMANN, R
BUTTKUS, U
ALTMANN, KH
机构：
[1] Séction de chimie, Université de Lausanne, Lausanne, CH-1005
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 11期
关键词：
D O I：
10.1002/anie.199115141
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The interconversion of two secondary structure types (alpha-helix reversible beta-sheet) induced by external conditions such as pH, temperature, concentration, and solvent could be proved in a new class of amphiphilic peptides (switch peptides) in aqueous solution. The pH-dependent conformational changes were studied by CD spectroscopy. Special attention was given to the investigations of four newly synthesized peptides with similar sequences.
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收藏
页码：1514 / 1516
页数：3
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