Hyaluronic acid in combination with chondroitin sulfate and hyaluronic acid improved the degeneration of synovium and cartilage equally in rabbits with osteoarthritis

被引：9
作者：
Chen, Lei [1 ,2 ]
Ling, Peixue [1 ]
Jin, Yan [1 ]
Zhang, Tianmin [3 ]
机构：
[1] Shandong Acad Pharmaceut Sci, Xinluo Dajie 989, Jinan 250101, Shandong, Peoples R China
[2] Shandong Bausch & Lomb Freda Co Ltd, Jinan, Shandong, Peoples R China
[3] Shandong Univ, Sch Pharmaceut Sci, Jinan, Shandong, Peoples R China
来源：
DRUG DISCOVERIES AND THERAPEUTICS | 2011年 / 5卷 / 04期
关键词：
Osteoarthritis; histological evaluation; Mankin score; biochemical evaluation;
D O I：
10.5582/ddt.2011.v5.4.190
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The purpose of this study was to compare the chondroprotective effects of chondroitin sulfate (CS)-hyaluronic acid (HA) (CS-HA) injection and HA injection in an experimental model of osteoarthritis. After induction of osteoarthritis in rabbits, 28 rabbits were randomized into four groups: control group, 'HA' group, 'CS' group, and 'CS-HA' group. After 7 days, rabbits in the control group, 'HA' group, 'CS' group and 'CSHA' group were respectively treated with normal saline, HA, CS, or CS-HA injection in the knees. All animals were treated once weekly. The animals were treated continuously for 5 weeks. Histological and biochemical evaluations were performed. As shown by histological observation, CS-HA injection treatment showed a chondroprotective effect on osteoarthritis. However, the histological scores of 'HA' group and 'CS-HA' group were not significantly different (p > 0.05). The results of biochemical evaluation showed that the expression levels of IL-1 beta, TNF-alpha, TIMP-1 and NO in synovial fluid of treated groups were all different from the control group (p < 0.05). However, the expression levels of these biochemical molecules in three treated groups were not significantly different (p > 0.05). In conclusion, CS-HA injection showed no obvious advantage over HA injection in osteoarthritis treatment.
引用
收藏
页码：190 / 194
页数：5
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