PREVALENCE OF THE TYPE-I COMPLEMENT C2 DEFICIENCY GENE IN SWEDISH SYSTEMIC LUPUS-ERYTHEMATOSUS PATIENTS

被引：23

作者：

TRUEDSSON, L ^{[1
]}

STURFELT, G ^{[1
]}

NIVED, O ^{[1
]}

机构：

[1] LUND UNIV,DEPT RHEUMATOL,S-22362 LUND,SWEDEN

来源：

LUPUS | 1993年 / 2卷 / 05期

关键词：

COMPLEMENT; COMPLEMENT C2; COMPLEMENT DEFICIENCY; SYSTEMIC LUPUS; ERYTHEMATOSUS;

D O I：

10.1177/096120339300200509

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prevalence of type I complement C2 deficiency in Swedish systemic lupus erythematosus (SLE) patients was investigated by DNA analysis. The characteristic 28 base pair deletion was determined by polymerase chain reaction analysis followed by gel electrophoresis. Five of the 86 patients (5.8%) retrieved from a defined population of 160 000 individuals were heterozygous for the C2Q0 gene compared with one heterozygote of 100 local blood donors (1%), the difference in prevalence not being significant. Among 26 other SLE patients, two patients who are siblings were C2Q0 homozygous. No distinctive clinical features among the patients with C2Q0 genes were obvious, although none had renal involvement.

引用

页码：325 / 327

页数：3

共 16 条

[1]

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[2] SERUM COMPLEMENT SUPERGENES OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN MAN (COMPLOTYPES) [J].