INDUCTION OF THERMOTOLERANCE IN T-CELLS PROTECTS NUCLEAR-DNA TOPOISOMERASE-I FROM HEAT-STRESS

被引：6

作者：

CIAVARRA, RP ^{[1
]}

DUVALL, W ^{[1
]}

CASTORA, FJ ^{[1
]}

机构：

[1] EASTERN VIRGINIA MED SCH,DEPT BIOCHEM,NORFOLK,VA 23507

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)80789-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we have demonstrated that topoisomerase I DNA relaxing activity i protected against a severe heat shock in T cells made thermotolerant by a prior modes heat treatment. However, following a severe heat-shock challenge and incubation a 37°C, topoisomerase activity in the control population eventually returned to level similar to those detected in thermotolerant cells. This recovery of topoisomeras activity appears to result from the renaturation of heat-inactivated enzyme rather tha from synthesis of new protein because the rate of recovery of catalytic activity was no inhibited by the presence of the protein synthesis inhibitor, cycloheximide. © 1992 Academic Press, Inc.

引用

页码：166 / 172

页数：7

共 43 条

[21] HST-1/FGF-4 protects male germ cells from apoptosis under heat-stress condition [J].

Hirai, K ;

Sasaki, H ;

Yamamoto, H ;

Sakamoto, J ;

Kubota, Y ;

Kakizoe, T ;

Terada, M ;

Ochiya, T .

EXPERIMENTAL CELL RESEARCH, 2004, 294 (01) :77-85

[22] EFFECT OF DNA TOPOISOMERASE-I INHIBITOR, 10-HYDROXYCAMPTOTHECIN, ON THE STRUCTURE AND FUNCTION OF NUCLEI AND NUCLEAR MATRIX IN BLADDER-CARCINOMA MBT-2 CELLS [J].

LING, YH ;

PEREZSOLER, R ;

TSENG, MT .

ANTICANCER RESEARCH, 1993, 13 (5A) :1613-1617

[23] Induction of apoptosis and inhibition of DNA topoisomerase-I in K-562 cells by a marine microalgal polysaccharide (Retraction of vol 66, pg PL227, 2000) [J].

Sogawa, K ;

Yamada, T ;

Sumida, T ;

Hamakawa, H ;

Kuwabara, H ;

Matsuda, M ;

Muramatsu, Y ;

Kose, H ;

Matsumoto, K ;

Sasaki, Y ;

Okutani, K ;

Kondo, K ;

Monden, Y .

LIFE SCIENCES, 2002, 71 (21) :2575-2575

[24] RETRACTED: Induction of apoptosis and inhibition of DNA topoisomerase-I in K-562 cells by a marine microalgal polysaccharide (Retracted Article. See vol 71, pg 2575, 2002) [J].

Sogawa, K ;

Yamada, T ;

Sumida, T ;

Hamakawa, H ;

Kuwabara, H ;

Matsuda, M ;

Muramatsu, Y ;

Kose, H ;

Matsumoto, K ;

Sasaki, Y ;

Okutani, K ;

Kondo, K ;

Monden, Y .

LIFE SCIENCES, 2000, 66 (16) :PL227-PL231

[25] MILD HEAT-STRESS STIMULATES NA+/H+ EXCHANGE IN FROG OXYNTICOPEPTIC CELLS AND PROTECTS GASTRIC-MUCOSA FROM LUMINAL ACID [J].

YANAKA, A ;

FUNAYAMA, N ;

YOKOTA, H ;

MUTO, H .

GASTROENTEROLOGY, 1993, 104 (04) :A227-A227

[26] DNA TOPOISOMERASE-I AND TOPOISOMERASE-II ACTIVITIES DURING CELL-PROLIFERATION AND THE CELL-CYCLE IN CULTURED MOUSE EMBRYO FIBROBLAST (C3H 10T1/2) CELLS [J].

TRICOLI, JV ;

SAHAI, BM ;

MCCORMICK, PJ ;

JARLINSKI, SJ ;

BERTRAM, JS ;

KOWALSKI, D .

EXPERIMENTAL CELL RESEARCH, 1985, 158 (01) :1-14

[27] Induction of heat shock proteins (HSP) protects RIN cells from interleukin 1 beta (IL)-induced DNA damage [J].

Dunger, A ;

Ziegler, B ;

Schmidt, S ;

Fischer, U .

DIABETES, 1996, 45 :877-877

[28] Clonally expanded T cells from skin biopsies of patients with systemic sclerosis recognize DNA topoisomerase I and cytomegalovirus antigens [J].

Zacharakis, Nikolaos ;

Oleszak, Emilia ;

Gaughan, John ;

Nanajian, Anthony ;

Myers, Allen ;

Tsygankov, Alexander ;

Platsoucas, Chris .

JOURNAL OF IMMUNOLOGY, 2015, 194

[29] TRANSFECTION-MEDIATED EXPRESSION OF HUMAN HSP70I PROTECTS RAT DORSAL-ROOT GANGLION NEURONS AND GLIA FROM SEVERE HEAT-STRESS [J].

UNEY, JB ;

KEW, JNC ;

STALEY, K ;

TYERS, P ;

SOFRONIEW, MV .

FEBS LETTERS, 1993, 334 (03) :313-316

[30] Hydrodynamic vaccination with DNA encoding an immunologically privileged retinal antigen protects from autoimmunity through induction of regulatory T cells [J].

Silver, Phyllis B. ;

Agarwal, Rajeev K. ;

Su, Shao-Bo ;

Suffia, Isabelle ;

Grajewski, Rafael S. ;

Luger, Dror ;

Chan, Chi-Chao ;

Mahdi, Rashid M. ;

Nickerson, John M. ;

Caspi, Rachel R. .

JOURNAL OF IMMUNOLOGY, 2007, 179 (08) :5146-5158

← 1 2 3 4 5 →