ANGIOTENSIN-II INDUCES FORMATION OF THE EARLY GROWTH-RESPONSE GENE-1 PROTEIN IN RAT VASCULAR SMOOTH-MUSCLE CELLS

被引：17

作者：

SACHINIDIS, A

WEISSER, P

KO, Y

SCHULTE, K

BRICKWEDDE, KMZ

NEYSES, L

VETTER, H

机构：

[1] Medizinische Universitäts-Poliklinik, D-5300 Bonn 1, Wilhelmstr

来源：

FEBS LETTERS | 1992年 / 313卷 / 02期

关键词：

EARLY GROWTH RESPONSE GENE-1 (EGR-1); ANGIOTENSIN-II; VASCULAR SMOOTH MUSCLE CELL;

D O I：

10.1016/0014-5793(92)81423-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor antagonist. Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1 protein, with a maximum at 30 min and 60 min, respectively. EXP3174 blocked the Ang II-induced increase of inositolphosphates, Egr-1 mRNA and the Egr-1 protein, suggesting the involvement of the PI signalling system by the expression of the Egr-1 gene.

引用

页码：109 / 112

页数：4

共 13 条

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