Opportunistic lung infections as a manifestation of Good's syndrome

被引：1

作者：

Kim, Suk Yeon ^{[1
]}

Kim, Joo-Hee ^{[1
]}

Hwang, Ha Won ^{[1
]}

Kim, Kwang Youn ^{[1
]}

Park, Sunghoon ^{[1
]}

Hwang, Young Il ^{[1
]}

Jang, Seung Hun ^{[1
]}

Jung, Ki-Suck ^{[1
]}

机构：

[1] Hallym Univ, Sacred Heart Hosp, Coll Med, Dept Internal Med, Anyang, South Korea

来源：

ALLERGY ASTHMA & RESPIRATORY DISEASE | 2015年 / 3卷 / 05期

关键词：

Good's syndrome; Thymoma; Hypogammaglobulinemia; Pneumonia; Opportunistic infections;

D O I：

10.4168/aard.2015.3.5.365

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Good's syndrome is an acquired immunodeficiency state associated with thymoma. It is characterized by recurrent infection, autoimmune disease, and immunologic abnormality. The insufficient immunity can be managed by intravenous immunoglobulin (IVIG) replacement therapy. We describe 2 patients who presented with Pneumocystis jiroveci pneumonia and Cytomegalovirus pneumonia after thymectomy for a thymoma. Immunologic study revealed hypogammaglobulinemia with very low B-cell count, consistent with Good's syndrome. They were successfully treated with trimethoprim/sulfamethoxazole and gancyclovir respectively, and they are all well without additional infections, receiving regular IVIG replacement.

引用

页码：365 / 369

页数：5

共 18 条

[1] Thymoma and immunodeficiency (Good syndrome): a report of 2 unusual cases and review of the literature [J].

Agarwal, Shradha ;

Cunningham-Rundles, Charlotte .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2007, 98 (02) :185-190

[2] Primary immunodeficiency diseases: an update on the classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency [J].

Al-Herz, Waleed ;

Bousfiha, Aziz ;

Casanova, Jean-Laurent ;

Chatila, Talal ;

Conley, Mary Ellen ;

Cunningham-Rundles, Charlotte ;

Etzioni, Amos ;

Franco, Jose Luis ;

Gaspar, H. Bobby ;

Holland, Steven M. ;

Klein, Christoph ;

Nonoyama, Shigeaki ;

Ochs, Hans D. ;

Oksenhendler, Erik ;

Picard, Capucine ;

Puck, Jennifer M. ;

Sullivan, Kate ;

Tang, Mimi L. K. .

FRONTIERS IN IMMUNOLOGY, 2014, 5

[3] Evaluation of the adult with suspected immunodeficiency [J].

Azar, Antoine E. ;

Ballas, Zuhair K. .

AMERICAN JOURNAL OF MEDICINE, 2007, 120 (09) :764-768

[4] Biologic IgG level in primary immunodeficiency disease: The IgG level that protects against recurrent infection [J].

Bonagura, Vincent R. ;

Marchlewski, Robert ;

Cox, Amanda ;

Rosenthal, David W. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2008, 122 (01) :210-212

[5]

김혜인, 2011, [The Korean Journal of Medicine, 대한내과학회지], V81, P266

[6]

HAYWARD AR, 1982, CLIN EXP IMMUNOL, V48, P437

[7] Good's syndrome remains a mystery after 55 years: A systematic review of the scientific evidence [J].

Kelesidis, Theodoros ;

Yang, Otto .

CLINICAL IMMUNOLOGY, 2010, 135 (03) :347-363

[8] What is Good's syndrome? Immunological abnormalities in patients with thymoma [J].

Kelleher, P ;

Misbah, SA .

JOURNAL OF CLINICAL PATHOLOGY, 2003, 56 (01) :12-16

[9]

Kim GW, 2002, J ASTHMA ALLERGY CLI, V22, P142

[10]

Kim JY, 2008, KOREAN J MED S3, V75, P935

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