THE EMERGENCE OF A HIGHLY TRANSMISSIBLE LINEAGE OF CBL(+) PSEUDOMONAS (BURKHOLDERIA) CEPACIA CAUSING CF CENTER EPIDEMICS IN NORTH-AMERICA AND BRITAIN

被引：180

作者：

SUN, L

JIANG, RZ

STEINBACH, S

HOLMES, A

CAMPANELLI, C

FORSTNER, J

SAJJAN, U

TAN, Y

RILEY, M

GOLDSTEIN, R

机构：

[1] BOSTON UNIV,SCH MED,MAXWELL FINLAND LAB INFECT DIS,MOLEC GENET SECT,BOSTON,MA 02118

[2] BOSTON CITY HOSP,BOSTON,MA 02118

[3] BOSTON UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02118

[4] HOSP SICK CHILDREN,DIV BIOCHEM,RES INST,TORONTO,ON M5G 1X8,CANADA

[5] YALE UNIV,DEPT BIOL,NEW HAVEN,CT 06511

来源：

NATURE MEDICINE | 1995年 / 1卷 / 07期

关键词：

D O I：

10.1038/nm0795-661

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The rapid increase in Pseudomonas (Burkholderia) cepacia infection in cystic fibrosis (CF) patients suggests epidemic transmission, but the degree of transmissibility remains controversial as conflicting conclusions have been drawn from studies at different CF centres. This report provides the first DNA sequence-based documentation of a divergent evolutionary lineage of P. cepacia associated with CF centre epidemics in North America (Toronto) and Europe (Edinburgh). The involved epidemic clone encoded and expressed novel cable (Cbl) pill that bind to CF mucin. The sequence of the cblA pilin subunit gene carried by the epidemic isolates proved to be invariant. Although it remains to be determined how many distinct, highly transmissible lineages exist, our results provide both a DNA sequence and chromosomal fingerprint that can be used to screen for one such particularly infectious, transatlantic clone.

引用

页码：661 / 666

页数：6

共 27 条

[21] SEQUENCE INVARIANCE OF THE ANTIGEN-CODING CENTRAL REGION OF THE PHASE-1 FLAGELLAR FILAMENT GENE (FLIC) AMONG STRAINS OF SALMONELLA-TYPHIMURIUM [J].