S6 PHOSPHORYLATION ACCOMPANIES RECRUITMENT OF RIBOSOMES AND MESSENGER-RNA INTO POLYSOMES IN RESPONSE TO DICHLORORIBOFURANOSYL BENZIMIDAZOLE

被引：7

作者：

DUNCAN, R ^{[1
]}

MCCONKEY, EH ^{[1
]}

机构：

[1] UNIV COLORADO, DEPT MOLEC CELLULAR & DEV BIOL, BOULDER, CO 80309 USA

来源：

EXPERIMENTAL CELL RESEARCH | 1984年 / 152卷 / 02期

关键词：

D O I：

10.1016/0014-4827(84)90654-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dichlororibofuranosyl benzimidazole (DRB), a potent inhibitor of nuclear RNA synthesis and mRNA accumulation, produces a paradoxical mobilization of rRNA and mRNA from the subpolysomal pool into polysomes in HeLa cells during the first 40 min of treatment. S6 is phosphorylated concurrently with polysome accumulation, and ribosomal subunits containing phosphorylated S6 are preferentially localized in polysomes, indicating that they form initiation complexes more readily than their nonphosphorylated counterparts.

引用

页码：520 / 527

页数：8

共 17 条

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