Lipid structure and Ca2+-ATPase function

被引：28

作者：

Lee, AG ^{[1
]}

Dalton, KA ^{[1
]}

Duggleby, RC ^{[1
]}

East, JM ^{[1
]}

Starling, AP ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON, INST BIOMOLEC SCI, SOUTHAMPTON SO9 3TU, HANTS, ENGLAND

来源：

BIOSCIENCE REPORTS | 1995年 / 15卷 / 05期

基金：

英国惠康基金;

关键词：

ATPase; calcium; phospholipid;

D O I：

10.1007/BF01788361

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Effects of lipid structure on the function of the Ca2+-ATPase of skeletal muscle of sarcoplasmic reticulum are reviewed. Binding of phospholipids to the ATPase shows little specificity. Phosphatidylcholines with short (C14) or long (C24) fatty acyl chains have marked effects on the activity of the ATPase, including a change in the stoichiometry of Ca binding. Low ATPase activity in gel phase lipid follows from low rate of phosphorylation. Phosphatidylinositol 4-phosphate increases ATPase activity by increasing the rate of dephosphorylation of the phosphorylated ATPase. Stimulation is not seen with other anionic phospholipids; phosphatidic acid decreases ATPase activity in a Mg2+-dependent manner.

引用

页码：289 / 298

页数：10

共 50 条

[1] LOCALIZATION OF THE HINGE REGION OF THE CA2+-ATPASE OF SARCOPLASMIC-RETICULUM USING RESONANCE ENERGY-TRANSFER [J].

BAKER, KJ ;

EAST, JM ;

LEE, AG .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1994, 1192 (01) :53-60

[2] FLUORESCENCE QUENCHING IN MODEL MEMBRANES .3. RELATIONSHIP BETWEEN CALCIUM ADENOSINE-TRIPHOSPHATASE ENZYME-ACTIVITY AND THE AFFINITY OF THE PROTEIN FOR PHOSPHATIDYLCHOLINES WITH DIFFERENT ACYL CHAIN CHARACTERISTICS [J].

CAFFREY, M ;

FEIGENSON, GW .

BIOCHEMISTRY, 1981, 20 (07) :1949-1961

[3] INFLUENCE OF METAL-IONS ON THE PHASE PROPERTIES OF PHOSPHATIDIC-ACID IN COMBINATION WITH NATURAL AND SYNTHETIC PHOSPHATIDYLCHOLINES - AN X-RAY-DIFFRACTION STUDY USING SYNCHROTRON RADIATION [J].

CAFFREY, M ;

FEIGENSON, GW .

BIOCHEMISTRY, 1984, 23 (02) :323-331

[4]

CLARKE DM, 1990, J BIOL CHEM, V265, P17405

[5] EFFECTS OF MEMBRANE THICKNESS ON THE MOLECULAR-DYNAMICS AND ENZYMATIC-ACTIVITY OF RECONSTITUTED CA-ATPASE [J].

CORNEA, RL ;

THOMAS, DD .

BIOCHEMISTRY, 1994, 33 (10) :2912-2920

[6]

DEMEIS L, 1981, SARCOPLASMIC RETICUL

[7] BINDING-SITES FOR CHOLESTEROL ON CA2+-ATPASE STUDIED BY USING A CHOLESTEROL-CONTAINING PHOSPHOLIPID [J].

DING, J ;

STARLING, AP ;

EAST, JM ;

LEE, AG .

BIOCHEMISTRY, 1994, 33 (16) :4974-4979

[8]

EAST JM, 1984, J BIOL CHEM, V259, P8070

[9] EXCHANGE-RATES AND NUMBERS OF ANNULAR LIPIDS FOR THE CALCIUM AND MAGNESIUM-ION DEPENDENT ADENOSINE-TRIPHOSPHATASE [J].

EAST, JM ;

MELVILLE, D ;

LEE, AG .

BIOCHEMISTRY, 1985, 24 (11) :2615-2623

[10] LIPID SELECTIVITY OF THE CALCIUM AND MAGNESIUM-ION DEPENDENT ADENOSINE-TRIPHOSPHATASE, STUDIED WITH FLUORESCENCE QUENCHING BY A BROMINATED PHOSPHOLIPID [J].

EAST, JM ;

LEE, AG .

BIOCHEMISTRY, 1982, 21 (17) :4144-4151

← 1 2 3 4 5 →