SYNTHESIS OF RACEMIC CARBOCYCLIC CYCLOPROPANOID NUCLEOSIDE ANALOGS

被引：38

作者：

CSUK, R

VONSCHOLZ, Y

机构：

[1] Pharmazeutisch-Chemisches Institut, Universität Heidelberg, D-69120 Heidelberg

来源：

TETRAHEDRON | 1995年 / 51卷 / 26期

关键词：

D O I：

10.1016/0040-4020(95)00367-H

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

As further representatives of a novel class of carbocyclic nucleoside analogues (+/-)-cis- and (+/-)trans-(2-hydroxymethylcyclopropyl)-uracil, -thymine, and -inosine were synthesized from the corresponding dialkyl 1,2-cyclopropane dicarboxylates.

引用

页码：7193 / 7206

页数：14

共 36 条

[1] ENANTIOSELECTIVE SYNTHESIS OF NEW ANALOGS OF NEPLANOCIN A AND THEIR BIOLOGICAL-ACTIVITY [J].

ARITA, M ;

OKUMOTO, T ;

SAITO, T ;

HOSHINO, Y ;

FUKUKAWA, K ;

SHUTO, S ;

TSUJINO, M ;

SAKAKIBARA, H ;

OHNO, M .

CARBOHYDRATE RESEARCH, 1987, 171 :233-258

[2] SYNTHESIS AND ANTIHERPETIC ACTIVITY OF (+/-)-9-[[(Z)-2-(HYDROXYMETHYL)CYCLOPROPYL]METHYL]GUANINE AND RELATED-COMPOUNDS [J].

ASHTON, WT ;

MEURER, LC ;

CANTONE, CL ;

FIELD, AK ;

HANNAH, J ;

KARKAS, JD ;

LIOU, R ;

PATEL, GF ;

PERRY, HC ;

WAGNER, AF ;

WALTON, E ;

TOLMAN, RL .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (12) :2304-2315

[3]

BIEBER P, 1951, CR HEBD ACAD SCI, V233, P655

[4] RING-OPENING REACTIONS OF CERTAIN 2-CARBONYL-SUBSTITUTED CYCLOPROPYLAMINES [J].

CANNON, JG ;

GARST, JE .

JOURNAL OF ORGANIC CHEMISTRY, 1975, 40 (02) :182-184

[5] SYNTHESIS OF CYCLOPROPYL CARBOCYCLIC NUCLEOSIDES [J].

CSUK, R ;

VONSCHOLZ, Y .

TETRAHEDRON, 1994, 50 (35) :10431-10442

[6] S-ADENOSYLHOMOCYSTEINE HYDROLASE INHIBITORS AS BROAD-SPECTRUM ANTIVIRAL AGENTS [J].

DECLERCQ, E .

BIOCHEMICAL PHARMACOLOGY, 1987, 36 (16) :2567-2575

[7] ANTIVIRAL AND ANTIMETABOLIC ACTIVITIES OF NEPLANOCINS [J].

DECLERCQ, E .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 28 (01) :84-89

[8] ENOL ETHERS .6. SYNTHESES WITH BETA-ETHOXYACRYLIC ACID CHLORIDES [J].

EFFENBERGER, F ;

HARTMANN, W .

CHEMISCHE BERICHTE-RECUEIL, 1969, 102 (10) :3260-+

[9] SELECTIVITY OF ACTION OF AN ANTI-HERPETIC AGENT, 9-(2-HYDROXYETHOXYMETHYL)GUANINE [J].

ELION, GB ;

FURMAN, PA ;

FYFE, JA ;

DEMIRANDA, P ;

BEAUCHAMP, L ;

SCHAEFFER, HJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5716-5720

[10] 9-([2-HYDROXY-1-(HYDROXYMETHYL)ETHOXY]METHYL)GUANINE - A SELECTIVE INHIBITOR OF HERPES GROUP VIRUS-REPLICATION [J].

FIELD, AK ;

DAVIES, ME ;

DEWITT, C ;

PERRY, HC ;

LIOU, R ;

GERMERSHAUSEN, J ;

KARKAS, JD ;

ASHTON, WT ;

JOHNSTON, DBR ;

TOLMAN, RL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (13) :4139-4143

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