PLATELET SEROTONINERGIC SYSTEM IN PATIENTS WITH ESSENTIAL-HYPERTENSION

被引：0

作者：

KRIVONKIN, KY ^{[1
]}

BELOUSOV, YB ^{[1
]}

BRUSOV, OS ^{[1
]}

KATASONOV, AB ^{[1
]}

ZLOBINA, GP ^{[1
]}

FAKTOR, MI ^{[1
]}

机构：

[1] RUSSIAN ACAD MED SCI,MENTAL HLTH RES CTR,INST CLIN PSYCHIAT,CLIN BIOCHEM LAB,MOSCOW,RUSSIA

来源：

KARDIOLOGIYA | 1992年 / 32卷 / 11-12期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To investigate if there can be alterations in the 5-hydroxytryptamine (5-HT) uptake system in the sensitivity of platelets in patients with essential hypertension, 38 hypertensive patients and 37 normotensive healthy subjects were compared in patients, the maximal 5-HT uptake velocity was reduced. The density of binding sites for H-3-imipramine was elevated in hypertensive females, but unchanged in males. The sensitivity of 5-HT uptake to trazodone was unchanged in patients. Half-maximal concentrations of 5-HT for inducing a shape change reaction of platelets were positively correlated with diastolic blood pressure in male patients and were reduced in female mild hypertensives. It is suggested that these changes are likely to be involved in the pathogenesis of hypertension.

引用

页码：10 / 12

页数：3

共 21 条

[1] 5-HYDROXYTRYPTAMINE IN BLOOD-PLATELETS OF CIRRHOTIC AND HYPERTENSIVE PATIENTS [J].

AHTEE, L ;

PENTIKAINEN, L ;

PENTIKAINEN, PJ ;

PAASONEN, MK .

EXPERIENTIA, 1974, 30 (11) :1328-1329

[2]

BELOUSOV YB, 1973, KARDIOLOGIYA, P27

[3]

BELOUSOV YB, 1992, KARDIOLOGIYA, P3

[4] UPTAKE OF SEROTONIN BY HUMAN-PLATELETS AND ITS RELEVANCE TO CNS INVOLVEMENT IN HYPERTENSION [J].

BHARGAVA, KP ;

RAINA, N ;

MISRA, N ;

SHANKER, K ;

VRAT, S .

LIFE SCIENCES, 1979, 25 (02) :195-199

[5]

BIONDI ML, 1986, J HYPERTENS, V4, pS39

[6]

BRUSOV OS, 1985, B EKSP BIOL MED, P26

[7]

BRUSOV OS, 1988, ZH NEVROPATOL PSIKH, P96

[8]

BUHLER FR, 1987, J CARDIOVASC PHARM, V10, pS32

[9] 5-HYDROXYTRYPTAMINE KINETICS AND ACTIVATION OF BLOOD-PLATELETS IN PATIENTS WITH ESSENTIAL-HYPERTENSION [J].

FETKOVSKA, N ;

AMSTEIN, R ;

FERRACIN, F ;

REGENASS, M ;

BUHLER, FR ;

PLETSCHER, A .

HYPERTENSION, 1990, 15 (03) :267-273

[10] LOCAL PLATELET ACTIVATION CAUSES VASOCONSTRICTION OF LARGE EPICARDIAL CANINE CORONARY-ARTERIES INVIVO - THROMBOXANE-A2 AND SEROTONIN ARE POSSIBLE MEDIATORS [J].

GOLINO, P ;

ASHTON, JH ;

BUJA, LM ;

ROSOLOWSKY, M ;

TAYLOR, AL ;

MCNATT, J ;

CAMPBELL, WB ;

WILLERSON, JT .

CIRCULATION, 1989, 79 (01) :154-166

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