INCREASED SERUM LEVELS OF SOLUBLE INTERLEUKIN-2 RECEPTORS IN PATIENTS WITH BETA-THALASSEMIA MAJOR

被引：0

作者：

MORABITO, F

IACOPINO, P

LENTINI, M

LUISE, F

MARINO, A

PIROMALLI, A

NOBILE, F

机构：

来源：

RIVISTA ITALIANA DI PEDIATRIA-ITALIAN JOURNAL OF PEDIATRICS | 1992年 / 18卷 / 03期

关键词：

THALASSEMIA MAJOR; TRANSFUSION; SIL-2R; IMMUNOLOGY;

D O I：

暂无

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Serum levels of soluble Interleukine-2 Receptor (sIL-2R) were investigated in 46 transfusion-dependent Thalassemia Major patients (TM). The values were statistically higher in patients than in normal controls and well correlated with transfusion requirement. In order to identify the peripheral cell population responsible for the high sIL-2R released, we measured sIL-2R levels in the supernates of both unstimulated and lectin-activated peripheral monocytes, T and non-T lymphocytes. Data suggest that T lymphocytes appear to be the major source of the high serum level of sIL-2R in TM.

引用

页码：272 / 274

页数：3