PYRIDOXAL 5'-PHOSPHATE MEDIATED INACTIVATION OF ESCHERICHIA-COLI DNA-POLYMERASE-I - IDENTIFICATION OF LYSINE-635 AS AN ESSENTIAL RESIDUE FOR THE PROCESSIVE MODE OF DNA-SYNTHESIS

被引：35

作者：

BASU, S ^{[1
]}

BASU, A ^{[1
]}

MODAK, MJ ^{[1
]}

机构：

[1] UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,DEPT BIOCHEM,NEWARK,NJ 07103

来源：

BIOCHEMISTRY | 1988年 / 27卷 / 18期

关键词：

D O I：

10.1021/bi00418a011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：6710 / 6716

页数：7

共 19 条

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[2]

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MODAK, MJ .

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[5]

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[6] NUCLEAR OVERHAUSER EFFECT STUDIES OF THE CONFORMATIONS AND BINDING-SITE ENVIRONMENTS OF DEOXYNUCLEOSIDE TRIPHOSPHATE SUBSTRATES BOUND TO DNA-POLYMERASE-I AND ITS LARGE FRAGMENT [J].

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[7] SITE-SPECIFIC MODIFICATION OF ESCHERICHIA-COLI DNA-POLYMERASE-I LARGE FRAGMENT WITH PYRIDOXAL 5'-PHOSPHATE [J].

HAZRA, AK ;

DETERAWADLEIGH, S ;

WILSON, SH .

BIOCHEMISTRY, 1984, 23 (09) :2073-2078

[8] CONSTRUCTION OF A PLASMID THAT OVERPRODUCES THE LARGE PROTEOLYTIC FRAGMENT (KLENOW FRAGMENT) OF DNA-POLYMERASE-I OF ESCHERICHIA-COLI [J].

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[9]

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[10]

MERRIL BM, 1984, J BIOL CHEM, V257, P1320

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