Oral field cancerization: an update on current concepts

被引：179

作者：

Mohan, Meenakshi ^{[1
]}

Jagannathan, Nithya ^{[1
]}

机构：

[1] Saveetha Univ, Saveetha Dent Coll, Dept Oral Pathol, 162,Poonamalle High Rd,Vellapanchavadi, Madras 600077, Tamil Nadu, India

来源：

ONCOLOGY REVIEWS | 2014年 / 8卷 / 01期

关键词：

cancerization; clone; field; patch; metastasis; tumor;

D O I：

10.4081/oncol.2014.244

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There always exists a field with genetically altered cells with a high risk of developing premalignant and malignant lesions. It may often happen that an individual stem cell is genetically altered and can cause the formation of a clone or a patch which is likely to turn into a tumor. This explains the higher recurrence rates following tumor resections. It is essential to identify and to treat this field in order to have greater chances to prevent cancer and achieve a better outcome. This article reports concepts, theories and markers for the assessment of field cancerization.

引用

页码：13 / 19

页数：7

共 95 条

[1]

Ahmed AM, 2013, J BIO SCI RES, V4, P4

[2] Identification of individuals at high risk for head and neck carcinogenesis using chromosome aneuploidy detected by fluorescence in situ hybridization [J].