VALIDATED CAPILLARY ELECTROPHORESIS METHOD FOR THE ASSAY OF A RANGE OF BASIC DRUGS

被引：44

作者：

ALTRIA, KD

FRAKE, P

GILL, I

HADGETT, T

KELLY, MA

RUDD, DR

机构：

[1] Analytical Evaluation Group, Glaxo Research and Development, Ware, Herts. SG12 ODP, Park Road

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1995年 / 13卷 / 08期

关键词：

BASIC DRUGS; CAPILLARY ELECTROPHORESIS; DRUG FORMULATIONS; INTERNAL STANDARD; VALIDATION;

D O I：

10.1016/0731-7085(95)01552-V

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A capillary electrophoresis method has been developed and validated for the analysis of a wide range of basic drugs. Acceptable precision was obtained by employing an internal standard. Optimal sensitivity was obtained using low UV wavelengths. An experimentally designed study showed the method to be robust. The method has advantages over HPLC in terms of simplicity, speed and cost. The method is now in routine use for identity confirmation and assay of both drug substance and formulations.

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收藏

页码：951 / 957

页数：7

相关论文

共 15 条

[1] DETERMINATION OF SULFONAMIDES IN PORK MEAT EXTRACTS BY CAPILLARY ZONE ELECTROPHORESIS [J].

ACKERMANS, MT ;

BECKERS, JL ;

EVERAERTS, FM ;

HOOGLAND, H ;

TOMASSEN, MJH .

JOURNAL OF CHROMATOGRAPHY, 1992, 596 (01) :101-109

[2]

ALTRIA KD, 1995, LC GC-MAG SEP SCI, V13, P40

[3] ESSENTIAL PEAK AREA NORMALIZATION FOR QUANTITATIVE IMPURITY CONTENT DETERMINATION BY CAPILLARY ELECTROPHORESIS [J].

ALTRIA, KD .

CHROMATOGRAPHIA, 1993, 35 (3-4) :177-182

[4] APPLICATION OF CAPILLARY ELECTROPHORESIS AS A QUANTITATIVE IDENTITY TEST FOR PHARMACEUTICALS EMPLOYING AUTOMATED ON-COLUMN STANDARD ADDITION [J].

ALTRIA, KD ;

LUSCOMBE, DCM .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1993, 11 (4-5) :415-420

[5] THE APPLICATION OF EXPERIMENTAL-DESIGN TO THE ROBUSTNESS TESTING OF A METHOD FOR THE DETERMINATION OF DRUG-RELATED IMPURITIES BY CAPILLARY ELECTROPHORESIS [J].

ALTRIA, KD ;

FILBEY, SD .

CHROMATOGRAPHIA, 1994, 39 (5-6) :306-310

[6]

ALTRIA KD, 1994, CHROMATOGR ANAL APR, P3

[7]

ALTRIA KD, 1993, LC GC EUR, V6, P164

[8] APPLICATION OF A DIODE-ARRAY DETECTOR IN CAPILLARY ELECTROPHORESIS [J].

BECK, W ;

VANHOEK, R ;

ENGELHARDT, H .

ELECTROPHORESIS, 1993, 14 (5-6) :540-546

[9] REPRODUCIBLE AND HIGH-SPEED SEPARATION OF BASIC DRUGS BY CAPILLARY ZONE ELECTROPHORESIS [J].

CHEE, GL ;

WAN, TSM .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1993, 612 (01) :172-177

[10] THE VALIDATION OF ANALYTICAL METHODS FOR DRUG SUBSTANCES AND DRUG PRODUCTS IN UK PHARMACEUTICAL LABORATORIES [J].

CLARKE, GS .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1994, 12 (05) :643-652