ANALYSIS OF GENES AND CHROMOSOMES BY NONISOTOPIC INSITU HYBRIDIZATION

被引：224
作者：
LICHTER, P
BOYLE, AL
CREMER, T
WARD, DC
机构：
[1] INST HUMAN GENET & ANTHROPOL, HEIDELBERG, GERMANY
[2] YALE UNIV, SCH MED, DEPT HUMAN GENET, NEW HAVEN, CT 06510 USA
[3] YALE UNIV, SCH MED, DEPT MOLEC BIOPHYS & BIOCHEM, NEW HAVEN, CT 06510 USA
来源：
GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING | 1991年 / 8卷 / 01期
关键词：
D O I：
10.1016/1050-3862(91)90005-C
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Nonisotopic in situ hybridization is a powerful tool to analyze the organization of complex genomes. Current approaches utilizing this technique for the analysis of linear and spatial genome organizations are presented. Clinical applications of these approaches, which open new avenues for diagnosis of disease-related chromosomal changes, are also discussed.
引用
收藏
页码：24 / 35
页数：12
相关论文
共 166 条
[81]   HUMAN GENOME ORGANIZATION - ALU, LINES, AND THE MOLECULAR-STRUCTURE OF METAPHASE CHROMOSOME BANDS [J].
KORENBERG, JR ;
RYKOWSKI, MC .
CELL, 1988, 53 (03) :391-400
[82]   2-ACETYLAMINOFLUORENE-MODIFIED PROBES FOR THE INDIRECT HYBRIDOCYTOCHEMICAL DETECTION OF SPECIFIC NUCLEIC-ACID SEQUENCES [J].
LANDEGENT, JE ;
DEWAL, NJI ;
BAAN, RA ;
HOEIJMAKERS, JHJ ;
VANDERPLOEG, M .
EXPERIMENTAL CELL RESEARCH, 1984, 153 (01) :61-72
[83]   CHROMOSOMAL LOCALIZATION OF A UNIQUE GENE BY NON-AUTORADIOGRAPHIC INSITU HYBRIDIZATION [J].
LANDEGENT, JE ;
DEWAL, NJI ;
VANOMMEN, GJB ;
BAAS, F ;
DEVIJLDER, JJM ;
VANDUIJN, P ;
VANDERPLOEG, M .
NATURE, 1985, 317 (6033) :175-177
[84]   USE OF WHOLE COSMID CLONED GENOMIC SEQUENCES FOR CHROMOSOMAL LOCALIZATION BY NON-RADIOACTIVE INSITU HYBRIDIZATION [J].
LANDEGENT, JE ;
DEWAL, NJI ;
DIRKS, RW ;
BAAS, F ;
VANDERPLOEG, M .
HUMAN GENETICS, 1987, 77 (04) :366-370
[85]   ENZYMATIC-SYNTHESIS OF BIOTIN-LABELED POLYNUCLEOTIDES - NOVEL NUCLEIC-ACID AFFINITY PROBES [J].
LANGER, PR ;
WALDROP, AA ;
WARD, DC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :6633-6637
[86]  
LANGERSAFER PR, 1982, P NATL ACAD SCI-BIOL, V79, P4381, DOI 10.1073/pnas.79.14.4381
[87]  
LAWRENCE JB, 1985, NUCLEIC ACIDS RES, V13, P1777
[88]   INTERPHASE AND METAPHASE RESOLUTION OF DIFFERENT DISTANCES WITHIN THE HUMAN DYSTROPHIN GENE [J].
LAWRENCE, JB ;
SINGER, RH ;
MCNEIL, JA .
SCIENCE, 1990, 249 (4971) :928-932
[89]  
LAWRENCE JB, 1988, CELL, V52, P51
[90]   HIGHLY LOCALIZED TRACKS OF SPECIFIC TRANSCRIPTS WITHIN INTERPHASE NUCLEI VISUALIZED BY INSITU HYBRIDIZATION [J].
LAWRENCE, JB ;
SINGER, RH ;
MARSELLE, LM .
CELL, 1989, 57 (03) :493-502
45678910111213