ANALYSIS OF GENES AND CHROMOSOMES BY NONISOTOPIC INSITU HYBRIDIZATION

被引：224
作者：
LICHTER, P
BOYLE, AL
CREMER, T
WARD, DC
机构：
[1] INST HUMAN GENET & ANTHROPOL, HEIDELBERG, GERMANY
[2] YALE UNIV, SCH MED, DEPT HUMAN GENET, NEW HAVEN, CT 06510 USA
[3] YALE UNIV, SCH MED, DEPT MOLEC BIOPHYS & BIOCHEM, NEW HAVEN, CT 06510 USA
来源：
GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING | 1991年 / 8卷 / 01期
关键词：
D O I：
10.1016/1050-3862(91)90005-C
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Nonisotopic in situ hybridization is a powerful tool to analyze the organization of complex genomes. Current approaches utilizing this technique for the analysis of linear and spatial genome organizations are presented. Clinical applications of these approaches, which open new avenues for diagnosis of disease-related chromosomal changes, are also discussed.
引用
收藏
页码：24 / 35
页数：12
相关论文
共 166 条
[31]   THE USE OF CHROMOSOMAL TRANSLOCATIONS TO STUDY HUMAN-IMMUNOGLOBULIN GENE ORGANIZATION - MAPPING DH SEGMENTS WITHIN 35 KB OF THE C-MU GENE AND IDENTIFICATION OF A NEW DH LOCUS [J].
BULUWELA, L ;
ALBERTSON, DG ;
SHERRINGTON, P ;
RABBITTS, PH ;
SPURR, N ;
RABBITTS, TH .
EMBO JOURNAL, 1988, 7 (07) :2003-2010
[32]   DETECTION OF SINGLE-COPY GENES BY NONISOTOPIC INSITU HYBRIDIZATION ON HUMAN-CHROMOSOMES [J].
CHERIF, D ;
BERNARD, O ;
BERGER, R .
HUMAN GENETICS, 1989, 81 (04) :358-362
[33]   SIMULTANEOUS LOCALIZATION OF COSMIDS AND CHROMOSOME R-BANDING BY FLUORESCENCE MICROSCOPY - APPLICATION TO REGIONAL MAPPING OF HUMAN CHROMOSOME-11 [J].
CHERIF, D ;
JULIER, C ;
DELATTRE, O ;
DERRE, J ;
LATHROP, GM ;
BERGER, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) :6639-6643
[34]   CHROMOSOMAL LOCALIZATION OF AMPLIFIED C-MYC IN A HUMAN-COLON ADENOCARCINOMA CELL-LINE WITH A BIOTINYLATED PROBE [J].
CHERIF, D ;
LECONIAT, M ;
SUAREZ, HG ;
BERNHEIM, A ;
BERGER, R .
CANCER GENETICS AND CYTOGENETICS, 1988, 33 (02) :245-249
[35]   ARCHITECTURAL ORGANIZATION IN THE INTERPHASE NUCLEUS OF THE PROTOZOAN TRYPANOSOMA-BRUCEI - LOCATION OF TELOMERES AND MINICHROMOSOMES [J].
CHUNG, HMM ;
SHEA, C ;
FIELDS, S ;
TAUB, RN ;
VANDERPLOEG, LHT .
EMBO JOURNAL, 1990, 9 (08) :2611-2619
[36]  
COMINGS DE, 1968, AM J HUM GENET, V20, P440
[37]  
CREMER C, 1978, MICROSC ACTA, V81, P31
[38]   RAPID METAPHASE AND INTERPHASE DETECTION OF RADIATION-INDUCED CHROMOSOME-ABERRATIONS IN HUMAN-LYMPHOCYTES BY CHROMOSOMAL SUPPRESSION INSITU HYBRIDIZATION [J].
CREMER, T ;
POPP, S ;
EMMERICH, P ;
LICHTER, P ;
CREMER, C .
CYTOMETRY, 1990, 11 (01) :110-118
[39]   RABL MODEL OF THE INTERPHASE CHROMOSOME ARRANGEMENT TESTED IN CHINESE-HAMSTER CELLS BY PREMATURE CHROMOSOME CONDENSATION AND LASER-UV-MICROBEAM EXPERIMENTS [J].
CREMER, T ;
CREMER, C ;
BAUMANN, H ;
LUEDTKE, EK ;
SPERLING, K ;
TEUBER, V ;
ZORN, C .
HUMAN GENETICS, 1982, 60 (01) :46-56
[40]   RAPID INTERPHASE AND METAPHASE ASSESSMENT OF SPECIFIC CHROMOSOMAL CHANGES IN NEUROECTODERMAL TUMOR-CELLS BY INSITU HYBRIDIZATION WITH CHEMICALLY MODIFIED DNA PROBES [J].
CREMER, T ;
TESIN, D ;
HOPMAN, AHN ;
MANUELIDIS, L .
EXPERIMENTAL CELL RESEARCH, 1988, 176 (02) :199-220
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