AN IMPROVED SYNTHESIS OF ANTI-BENZO[C]PHENANTHRENE-3,4-DIOL 1,2-EPOXIDE VIA 4-METHOXYBENZO[C]PHENANTHRENE

被引：34
作者：
MISRA, B [1 ]
AMIN, S [1 ]
机构：
[1] AMER HLTH FDN,DIV CHEM CARCINOGENESIS,VALHALLA,NY 10595
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 14期
关键词：
D O I：
10.1021/jo00301a054
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Benzo[c]phenanthrene (1) is a relatively weak carcino-gen1widely distributed in the environment.2Metabolism of 1 on the benzo ring occurs almost exclusively at the 3,4-position to give trans-benzo[c]phenanthrene-3,4-diol3(2), the precursor to the bay region benzo[c]-phenanthrene-3,4-diol 1,2-epoxides (BcPhDE). BcPhDE exists as a pair of diastereoisomers: syn-BcPhDE (3). © 1990, American Chemical Society. All rights reserved.
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页码：4478 / 4480
页数：3
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