Impact of Oxidative Stress in Fetal Programming

被引：218
|
作者：
Thompson, Loren P. [1 ]
Al-Hasan, Yazan [1 ]
机构：
[1] Univ Maryland, Sch Med, Dept Obstet, Gynecol & Reprod Sci, 11-029 Bressler Res Bldg,655 W Baltimore St, Baltimore, MD 21201 USA
来源：
JOURNAL OF PREGNANCY | 2012年 / 2012卷
关键词：
D O I：
10.1155/2012/582748
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Intrauterine stress induces increased risk of adult disease through fetal programming mechanisms. Oxidative stress can be generated by several conditions, such as, prenatal hypoxia, maternal under-and overnutrition, and excessive glucocorticoid exposure. The role of oxidant molecules as signaling factors in fetal programming via epigenetic mechanisms is discussed. By linking oxidative stress with dysregulation of specific target genes, we may be able to develop therapeutic strategies that protect against organ dysfunction in the programmed offspring.
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页数：8
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