INFLUENCE OF THE INCORPORATION OF (S)-9-(3,4-DIHYDROXY-BUTYL)ADENINE ON THE ENZYMATIC STABILITY AND BASE-PAIRING PROPERTIES OF OLIGODEOXYNUCLEOTIDES

被引：47
作者：
AUGUSTYNS, K
VANAERSCHOT, A
VANSCHEPDAEL, A
URBANKE, C
HERDEWIJN, P
机构：
[1] REGA INST,MINDERBROEDERSSTR 10,B-3000 LOUVAIN,BELGIUM
[2] HANOVER MED SCH,W-3000 HANNOVER 61,GERMANY
来源：
NUCLEIC ACIDS RESEARCH | 1991年 / 19卷 / 10期
关键词：
D O I：
10.1093/nar/19.10.2587
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
(S)-9-(3,4-dihydroxybutyl)adenine was used at several positions as nucleoside substitute in the synthesis of dimers and 13-mers. Therefore we used the phosporamidite and the H-phosphonate chemistry. The nuclease susceptibilities and the base-pairing properties of these oligomers have been evaluated.
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页码：2587 / 2593
页数：7
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