THE INDUCTION AND SUBSEQUENT RETURN TO BASAL ACTIVITY OF LIVER-ENZYME ACTIVITY IN MALE C57BL/6 MICE AFTER A SINGLE ORAL DOSE OF 1,2,3,7,8-PNCDD OR 1,2,3,6,7,8-HXCDD

被引：1
作者：
DEJONGH, J
BELFROID, A
SINNIGE, T
SEINEN, W
VANDENBERG, M
机构：
[1] Environmental Toxicology Section, Research Institute Toxicology, University of Utrecht, 3508 TD Utrecht
来源：
CHEMOSPHERE | 1990年 / 20卷 / 7-9期
关键词：
D O I：
10.1016/0045-6535(90)90246-P
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The reduction of liver enzyme activity after an oral dose of 10 nmol/kg of 1,2,3,7,8-PnCDD (PnCDD) or 1,2,3,6,7,8-HxCDD (HxCDD) was followed in male mice of the C5/BL/6 strain. Two cytochrome P-450 related enzyme activities. EROD and PROD, were used as parameters for the induction of cytochrome P-450. For the PnCDD and HxCDD group, EROD activities were elevated 50 and 10 fold above control level on day 5. These elevations slowly declined, but were still significantly different from control level on day 54 for both groups. PROD activities were not elevated in both groups. Total cytochrome P-450 content of the PnCDD and HxCDD treated groups increased 3 and 2 fold and remained above control level until day 54 and 12 respectively. © 1990.
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页码：1203 / 1207
页数：5
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