PHENYTOIN-INDUCED CHRONIC HEPATITIS

被引：8

作者：

ROY, AK ^{[1
]}

MAHONEY, HC ^{[1
]}

LEVINE, RA ^{[1
]}

机构：

[1] SUNY HLTH SCI CTR,DEPT MED,SYRACUSE,NY 13210

来源：

DIGESTIVE DISEASES AND SCIENCES | 1993年 / 38卷 / 04期

关键词：

PHENYTOIN; AMINOTRANSFERASE; CHRONIC PERSISTENT HEPATITIS; RECHALLENGE; HEPATOTOXICITY;

D O I：

10.1007/BF01316808

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Phenytoin has been associated with acute hepatotoxicity. Chronic liver enzyme abnormalities associated with phenytoin have been attributed to enzyme induction. There have been no reports of phenytoin-induced chronic hepatitis. We describe an asymptomatic 52-year-old woman who received phenytoin sodium for 11 years and was found to have elevated serum aminotransferases. Assays for hepatitis A, B, and C were negative. Liver biopsy was performed and showed chronic persistent hepatitis. This documentation of phenytoin-induced chronic persistent hepatitis was proven by histology and its etiology confirmed by drug withdrawal and by rechallenge. Although uncommon, this entity is important to recognize in the differential diagnosis of asymptomatic chronic hepatic enzyme dysfunction. © 1993 Plenum Publishing Corporation.

引用

页码：740 / 743

页数：4

共 12 条

[1] THE EFFECTS OF PHENOBARBITAL AND DIPHENYLHYDANTOIN ON LIVER-FUNCTION AND MORPHOLOGY [J].