The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells - A data description

被引：8

作者：

Hongisto, Vesa ^{[1
]}

Aure, Miriam Ragle ^{[2
]}

Makela, Rami ^{[1
]}

Sahlberg, Kristine Kleivi ^{[2
,3
]}

机构：

[1] VTT Tech Res Ctr Finland, Turku, Finland

[2] Oslo Univ Hosp, Inst Canc Res, KG Jebsen Ctr Breast Canc, Dept Genet, Oslo, Norway

[3] Dept Res, Vestre Viken, Drammen, Norway

来源：

GENOMICS DATA | 2014年 / 2卷

基金：

芬兰科学院;

关键词：

HER2 positive breast cancer; aCGH; SiRNA; Lysate microarrays; Drug treatment;

D O I：

10.1016/j.gdata.2014.06.025

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A large number of breast cancers are characterized by amplification and overexpression of the chromosome segment surrounding the HER2 (ERBB2) oncogene. As theHER2 amplicon at 17q12 containsmultiple genes, we have systematically explored the role of the HER2 co-amplified genes in breast cancer cell growth and their relation to trastuzumab resistance. We integrated array comparative genomic hybridization (aCGH) data of the HER2 amplicon from 71 HER2 positive breast tumors and 10 cell lines with systematic functional RNA interference analysis of 23 core amplicon genes with several phenotypic endpoints in a panel of trastuzumab responding and non-responding HER2 positive breast cancer cells. In this Data in Brief we give a detailed description of the experimental procedures and the data analysis methods used in the study (1). (C) 2014 The Authors. Published by Elsevier Inc.

引用

页码：249 / 253

页数：5

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