PRE S1 ANTIGEN IN DIFFERENT FORMS OF HEPATITIS-B VIRUS-INFECTION

被引：0
作者：
BRAHM, J
HURTADO, C
ELGUETA, S
FUENTAS, C
VELASQUEZ, A
机构：
[1] UNIV CHILE,HOSP CLIN,CTR GASTROENTEROL,SANTIAGO,CHILE
[2] INST SALUD PUBL CHILE,HISTOCOMPATIBILIDAD LAB,SANTIAGO,CHILE
来源：
REVISTA MEDICA DE CHILE | 1995年 / 123卷 / 05期
关键词：
HEPATITIS; VIRAL; HUMAN; HEPATITIS B ANTIGENS; ENZYME-LINKED IMMUNOSORBENT ASSAY;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pre S1 antigen was measured using an ELISA technique in patients with different forms of hepatitis B virus infection. It was detected in 10 of 19 patients with acute hepatitis B (53%), 12 of 15 chronic hepatitis B virus carriers (80%), 9 of 11 patients with chronic hepatitis B (82%) and 3 of 4 patients with hepatoma and positive markers of hepatitis B virus infection. Pre S1 remained positive beyond 150 days in two patients with acute hepatitis that evolved to chronicity. Among subjects with chronic hepatitis B that received interferon, pre S1 antigen negativized only in the patient that had a complete response. Pre S1 detection is an index of hepatitis B virus replication and its persistence determines chronicity. Its negativization after antiviral therapy should have a predicitive value.
引用
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页码：567 / 570
页数：4
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