Elevation of macrophage-derived chemokine in eosinophilic pneumonia : a role of alveolar macrophages

被引：11
作者：
Manabe, Kazuyoshi
Nishioka, Yasuhiko
Kishi, Jun
Inayama, Mami
Aono, Yoshinori
Nakamura, Yoichi
Ogushi, Fumitaka
Bando, Hiroyasu
Tani, Kenji
Sone, Saburo
机构：
[1] Natl Kochi Hosp, Clin Res Ctr Allergy & Rheumatol, Kochi, Japan
[2] Tokushima Prefectural Cent Hosp, Dept Pulm Med, Tokushima, Japan
来源：
JOURNAL OF MEDICAL INVESTIGATION | 2005年 / 52卷 / 1-2期
关键词：
bronchoalveolar lavage fluid; macrophage-derived chemokine; thymus-and activation-regulated chemokine; eosinophilic pneumonia; alveolar macrophages; interstitial lung diseases;
D O I：
10.2152/jmi.52.85
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Macrophage-derived chemokine (MDC/CCL22) andthymus-andactivation-regulated chemokine (TARC/CCL17) are ligands for CC chemokine receptor 4. Recently, TARC has been reported to play a role in the pathogenesis of idiopathic eosinophilic pneumonia (IEP). The purpose of this study was to evaluate the role of MDC in IEP and other interstitial lung diseases (ILDs). MDC and TARC in the bronchoalveolar lavage fluid (BALF) were measured by enzyme-linked immunosorbent assay in patients with ILDs and healthy volunteers (HV). We also examined the expression of MDC mRNA in alveolar macrophages (AM) by real-time quantitative reverse transcriptase-polymerase chain reaction. Both MDC and TARC were detected only in BALF obtained from IEP patients. The concentration of MDC was higher than that of TARC in all cases. The level of MDC in IEP correlated with that of TARC. AM from IEP patients expressed a significantly higher amount of MDC than that from HV at the levels of protein and mRNA. MDC in BALF from IEP dramatically decreased when patients achieved remission. These findings suggest that MDC, in addition to TARC, might be involved in the pathogenesis of IEP, and AM play a role in the elevation of MDC in IEP.
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页码：85 / 92
页数：8
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