DISTRIBUTION OF GLUCOCORTICOID RECEPTOR MESSENGER-RNA IN THE RAT SPINAL-CORD

被引：28

作者：

MARLIER, LNJL

CSIKOS, T

REBAUDENGO, N

BORBONI, P

PATACCHIOLI, FR

ANGELUCCI, L

PRIVAT, A

LAURO, R

机构：

[1] GEORGETOWN UNIV,SCH MED,DEPT BIOCHEM & MOLEC BIOL,WASHINGTON,DC 20002

[2] UNIV TURIN,DEPT NEUROL,I-1000 TURIN,ITALY

[3] UNIV ROMA LA SAPIENZA,INST PHARMACOL,CHAIR 2,I-00185 ROME,ITALY

[4] USTL,DPVSN,INSERM,U336,F-34095 MONTPELLIER,FRANCE

来源：

NEUROREPORT | 1995年 / 6卷 / 16期

关键词：

CORTICOSTEROIDS; GLUCOCORTICOID RECEPTOR; MESSENGER-RNA; SPINAL CORD; MOTONEURON; DORSAL HORN; IN SITU HYBRIDIZATION HISTOCHEMISTRY;

D O I：

10.1097/00001756-199511000-00034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

USING in situ hybridization (ISH), we studied the distribution of rat glucocorticoid receptors (GR) mRNA in rat spinal cord. mRNA encoding for GR was abundant throughout the white matter and a clear pattern of distribution was detected within the grey matter. In the grey matter mRNA was primarily localized in the ventral horn, where motoneurones were strongly labelled. In the dorsal horn, the distribution appears more diffuse but the superficial layers (I and II) clearly exhibited a shigher signal. We conclude that, in rat spinal cord, GR are present in both glial and neuronal cells. In particular, both somatosensory and motor pathways contain GR.

引用

收藏

页码：2245 / 2249

页数：5

相关论文

共 26 条

[1] CHARTING OF TYPE-II GLUCOCORTICOID RECEPTOR-LIKE IMMUNOREACTIVITY IN THE RAT CENTRAL-NERVOUS-SYSTEM [J].

AHIMA, RS ;

HARLAN, RE .

NEUROSCIENCE, 1990, 39 (03) :579-604

[2]

ANGELUCCI L, 1980, PROGR PSYCHONEUROEND, P177

[3] LOCALIZATION OF GLUCOCORTICOID RECEPTOR MESSENGER-RNA IN THE MALE-RAT BRAIN BY INSITU HYBRIDIZATION [J].

ARONSSON, M ;

FUXE, K ;

DONG, Y ;

AGNATI, LF ;

OKRET, S ;

GUSTAFSSON, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) :9331-9335

[4] COLOCALIZATION OF FOS- AND GLUCOCORTICOID RECEPTOR-IMMUNOREACTIVITIES IS PRESENT ONLY IN A VERY RESTRICTED POPULATION OF DORSAL HORN NEURONS OF THE RAT SPINAL-CORD AFTER NOCICEPTIVE STIMULATION [J].

CINTRA, A ;

MOLANDER, C ;

FUXE, K .

BRAIN RESEARCH, 1993, 632 (1-2) :334-338

[5]

CLARK CR, 1987, BRAIN RES, V217, P412

[6] FUNCTIONS AND DYSFUNCTIONS OF RECEPTORS FOR ADRENAL CORTICOIDS IN THE CENTRAL NERVOUS-SYSTEM [J].

DENICOLA, AF ;

ORTI, E ;

MOSES, DF ;

MAGARINOS, AM ;

COIRINI, H .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1987, 27 (1-3) :599-607

[7] ADRENOCORTICOID ACTION IN THE SPINAL-CORD - SOME UNIQUE MOLECULAR-PROPERTIES OF GLUCOCORTICOID RECEPTORS [J].

DENICOLA, AF ;

MOSES, DF ;

GONZALEZ, S ;

ORTI, E .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 1989, 9 (02) :179-192

[8] TARGET NEURONS FOR [H-3] CORTICOSTERONE IN THE RAT SPINAL-CORD [J].

DUNCAN, GE ;

STUMPF, WE .

BRAIN RESEARCH, 1984, 307 (1-2) :321-326

[9] IMMUNOCYTOCHEMICAL LOCALIZATION OF GLUCOCORTICOID RECEPTORS IN THE SPINAL-CORD - EFFECTS OF ADRENALECTOMY, GLUCOCORTICOID TREATMENT, AND SPINAL-CORD TRANSECTION [J].

FERRINI, M ;

GONZALEZ, S ;

ANTAKLY, T ;

DENICOLA, AF .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 1993, 13 (04) :387-397

[10] IMMUNOCYTOCHEMICAL STUDIES ON THE LOCALIZATION OF GLUCOCORTICOID RECEPTOR IMMUNOREACTIVE NERVE-CELLS IN THE LOWER BRAIN-STEM AND SPINAL-CORD OF THE MALE-RAT USING A MONOCLONAL-ANTIBODY AGAINST RAT-LIVER GLUCOCORTICOID RECEPTOR [J].

FUXE, K ;

HARFSTRAND, A ;

AGNATI, LF ;

YU, ZY ;

CINTRA, A ;

WIKSTROM, AC ;

OKRET, S ;

CANTONI, E ;

GUSTAFSSON, JA .

NEUROSCIENCE LETTERS, 1985, 60 (01) :1-6