THE LOCAL LYMPH-NODE ASSAY - DEVELOPMENTS AND APPLICATIONS

被引：194
作者：
KIMBER, I [1 ]
DEARMAN, RJ [1 ]
SCHOLES, EW [1 ]
BASKETTER, DA [1 ]
机构：
[1] UNILEVER ENVIRONM SAFETY LAB,SHARNBROOK MK44 1LQ,BEDS,ENGLAND
来源：
TOXICOLOGY | 1994年 / 93卷 / 01期
关键词：
CONTACT SENSITIZATION; PREDICTIVE TESTING; LOCAL LYMPH NODE ASSAY;
D O I：
10.1016/0300-483X(94)90193-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The murine local lymph node assay is a predictive test method for the identification of contact allergens in which sensitizing activity is measured as a function of induced proliferative responses in lymph nodes draining the site of application. In this article the development and validation of the assay are described and comparisons with guinea pig predictive test methods discussed. In addition we examine the advantages and limitations of the method and consider new opportunities and applications of the assay in the context of the toxicological evaluation of sensitizing potential.
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页码：13 / 31
页数：19
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