SYSTEMIC EFFECTS OF SALBUTAMOL AND SALMETEROL IN PATIENTS WITH ASTHMA

Background - Knowing the extent of the systemic effects of a new beta(2) agonist relative to an established drug is important for the prediction and interpretation of side effects. A recent study in which the effect of cumulative doses of salbutamol was compared with single doses of salmeterol suggested that, weight for weight, salmeterol may be up to 10 times more potent than salbutamol. This current study was designed to investigate further the dose equivalence of salmeterol and salbutamol. Methods - Twelve patients with mild asthma inhaled cumulative doses of placebo, salmeterol 25, 50, 100, and 200 mu g, and salbutamol 100, 500, 1000, and 1000 mu g on separate days at hourly intervals in a randomised double blind crossover study. Changes in forced expiratory volume in one second (FEV(1)), heart rate, plasma potassium concentration, systolic and diastolic blood pressure were measured. Dose equivalence was determined as the dose ratio of salmeterol to salbutamol for the 50% maximum reponse to salbutamol. Results - No important changes occurred in any measurements following placebo. Salmeterol and salbutamol caused a near maximum increase in FEV(1) following the first dose so the dose equivalence for the airway effects could not be estimated. Heart rate increased and plasma potassium concentration and diastolic blood pressure decreased in a dose dependent manner following salmeterol and salbutamol, with median dose equivalences for salmeterol compared with salbutamol of 17.7, 7.8, and 7.6, respectively. Conclusions - These results confirm that the systemic activity of salmeterol compared with salbutamol is higher than would be expected from in vitro data, particularly for heart rate. Whether this is because of the relatively high dose of salmeterol used or pharmacokinetic differences between the two drugs is uncertain.