IDENTIFICATION, LOCALIZATION AND POSSIBLE ROLE OF CALMODULIN-LIKE PROTEIN IN PHOSPHOLIPID-SYNTHESIS OF MICROSPORUM-GYPSEUM

被引：4

作者：

BINDRA, A ^{[1
]}

GIRI, S ^{[1
]}

KHULLER, GK ^{[1
]}

机构：

[1] POSTGRAD INST MED EDUC & RES,DEPT BIOCHEM,CHANDIGARH 160012,INDIA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM | 1995年 / 1255卷 / 02期

关键词：

CALMODULIN; PHOSPHOLIPID SYNTHESIS; TRIFLUOPERAZINE; (M-GYPSEUM);

D O I：

10.1016/0005-2760(94)00226-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calmodulin like protein has been identified for the first time in dermatophyte - M. gypseum (by specific radioimmunoassay). Maximum amount of this protein was present in the early and mid log phase of growth and was mainly localized in the cytosolic fraction. Cells treated or grown with calmodulin antagonists (phenothiazine and trifluoperazine) exhibited lower uptake of [C-14]acetate or labelled phosphate into phospholipids. This is probably due to lower levels of calmodulin seen in these cells. Our results suggest the relationship between calmodulin levels and phospholipid synthesis in Microsporum gypseum.

引用

页码：118 / 122

页数：5

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