LEISHMANIA-TARENTOLAE TAXONOMIC RELATEDNESS INFERRED FROM PHYLOGENETIC ANALYSIS OF THE SMALL SUBUNIT RIBOSOMAL-RNA GENE

被引：52

作者：

BRIONES, MRS

NELSON, K

BEVERLEY, SM

AFFONSO, HT

CAMARGO, EP

FLOETERWINTER, LM

机构：

[1] UNIV SAO PAULO, INST CIENCIAS BIOMED ICB 2, DEPT PARASITOL CB, AV PROF LINEU PRESTES 1374, BR-05508 SAO PAULO, BRAZIL

[2] HARVARD UNIV, SCH MED, DEPT BIOL CHEM & MOLEC PHARMACOL, BOSTON, MA 02115 USA

[3] PENN STATE UNIV, INST MOLEC EVOLUTIONARY GENET, UNIV PK, PA 16802 USA

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1992年 / 53卷 / 1-2期

基金：

巴西圣保罗研究基金会;

关键词：

LEISHMANIA-TARENTOLAE; SSU RIBOSOMAL-RNA GENE; TRYPANOSOMATID PHYLOGENY;

D O I：

10.1016/0166-6851(92)90014-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sequence of the Leishmania tarentolae SSU rRNA (small subunit or 18S rRNA) gene was completely determined from 2 different strains and used to determine phylogenetic relationships between this organism and other trypanosomatids. Extensive structural similarities were observed between L. tarentolae and mammalian leishmanias the SSU rRNA. Phylogenetic reconstructions, using distance matrix or parsimony methods, showed large evolutionary distances between trypanosomes, either African and American, and L. tarentolae. Further analysis using intergenic rDNA spacer (IGS) sequences as probes in dot blot experiments confirmed the results obtained with the SSU rDNA comparisons. The data presented here clearly indicate that L. tarentolae is closely related to the mammalian parasite Leishmania donovani and highly divergent from trypanosomes.

引用

页码：121 / 128

页数：8

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