A SIMPLE ROUTE TO C-MONOSUBSTITUTED CARBORANE DERIVATIVES

被引：102

作者：

GOMEZ, FA ^{[1
]}

HAWTHORNE, MF ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,DEPT CHEM & BIOCHEM,LOS ANGELES,CA 90024

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 05期

关键词：

D O I：

10.1021/jo00031a016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A procedure is reported for the conversion of tert-butyldimethylsilyl chloride and closo-1,2-C2B10H12 (1) to the corresponding silylcarborane derivative 2 in 99% yield. Compound 2 served as a valuable synthon to other monosubstituted carboranyl derivatives. Lithiation and reaction at the carborane 2-vertex with a variety of mono- and difunctional electrophiles under mild conditions formed the corresponding silylated products. Subsequent deprotection with tetrabutylammonium fluoride produced the corresponding monosubstituted carborane derivatives in high yield.

引用

页码：1384 / 1390

页数：7

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