MOLECULAR-GENETICS OF DRUG-RESISTANCE IN PLASMODIUM-FALCIPARUM MALARIA

被引：42
作者：
WELLEMS, TE
机构：
[1] Thomas Wellems is at the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda
来源：
PARASITOLOGY TODAY | 1991年 / 7卷 / 05期
关键词：
D O I：
10.1016/0169-4758(91)90168-N
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Resistance to dihydrofolate reductase inhibitors and resistance to chloroquine have been mapped to single genetic loci in Plasmodium falciparum. Specific point mutations in the dihydrofolate reductase gene confer different degrees of resistance to two dihydrofolate inhibitors, cycloguanil and pyrimethamine, depending on the positions of the mutations and the residues involved. The chloroquine resistance locus has been mapped to a 400 kilobase (kb) segment of chromosome 7 in a P. falciparum cross. Identification and characterization of genes within this segment should lead to an understanding of the rapid drug efflux mechanism responsible for chloroquine resistance*.
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页码：110 / 112
页数：3
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