INTRACEREBROVENTRICULAR ADMINISTRATION OF A SPECIFIC IL-1 RECEPTOR ANTAGONIST BLOCKS FOOD AND WATER-INTAKE SUPPRESSION INDUCED BY INTERLEUKIN-1-BETA

被引：87

作者：

PLATASALAMAN, CR ^{[1
]}

FFRENCHMULLEN, JMH ^{[1
]}

机构：

[1] ICI AMER INC,ICI PHARMACEUT GRP,DEPT PHARMACOL,WILMINGTON,DE 19897

来源：

PHYSIOLOGY & BEHAVIOR | 1992年 / 51卷 / 06期

关键词：

INTERLEUKIN-1; GROWTH FACTOR; CYTOKINE; RECEPTOR ANTAGONIST; NEUROIMMUNOLOGY; IMMUNOMODULATOR; NERVOUS SYSTEM; IMMUNE SYSTEM; FEEDING; DRINKING; FOOD INTAKE; WATER INTAKE; RAT;

D O I：

10.1016/0031-9384(92)90321-R

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Intracerebroventricular (ICV) microinfusion of recombinant human interleukin-1-beta (rhIL-1-beta, 1.0 ng/rat) suppressed the short-term (2 h) food and water intakes in rats. ICV infusion of recombinant human IL-1 receptor antagonist (rhIL-1ra) had no effect on food or water intake. Concomitant ICV infusion of rhIL- 1-beta (1.0 ng/rat) and increasing concentrations of rhIL-1ra (25 to 1000 ng/rat) resulted in a dose-dependent inhibition of the short-term food and water intake suppression induced by rhIL-1-beta. The highest doses of rhIL-1ra (500 and 1000 ng/rat) completely blocked the food and water intake suppression induced by rhIL-1-beta. This suggests specificity of IL-1-beta suppression of short-term feeding and drinking by a direct action in the central nervous system (CNS). This ability of rhIL-1ra may have potential therapeutic implications in acute and chronic pathological processes associated with increased levels of IL-1 and appetite suppression.

引用

页码：1277 / 1279

页数：3

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