Zolpidem in Progressive Supranuclear Palsy

被引：11

作者：

Dash, Sandip K. ^{[1
]}

机构：

[1] Apollo Hosp Dhaka, Dept Neurol, Basundhara R-A, Dhaka 1229, Bangladesh

来源：

CASE REPORTS IN NEUROLOGICAL MEDICINE | 2013年 / 2013卷

关键词：

D O I：

10.1155/2013/250865

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disorder, characterized by motor symptoms, postural instability, personality changes, and cognitive impairment. There is no effective treatment for this disorder. Reduced neurotrans-mission of GABA in the striatum and globus pallidus may contribute to the symptoms of motor and cognitive symptoms seen in PSP. Zolpidem is a GABA agonist of the benzodiazepine subreceptor BZ1. Here a nondiabetic, normotensive case of PSP is (Progressive Supranuclear Palsy) described, which showed improvement in swallowing, speech, and gaze paresis after zolpidem therapy and possible mechanism of actions are discussed. However, more trials are needed with large number of patients to confirm the effectiveness of zolpidem in progressive supranuclear palsy.

引用

页数：2

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