P53 AND BEHAVIOR OF COLORECTAL-CANCER

被引：73

作者：

GOH, HS

CHAN, CS

KHINE, K

SMITH, DR

机构：

[1] Department of Colorectal Surgery, Singapore General Hospital, Outram Road

来源：

LANCET | 1994年 / 344卷 / 8917期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0140-6736(94)93000-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The tumour suppressor gene p53 is altered in most colorectal tumours. We found that lymphatic dissemination was driven by the presence of mutated p53 whether or not the cell contained wild-type p53. In a total sample of 187 specimens, point mutation of the p53 gene occurred in 70% and 43% of cases with and without lymph-node involvement, respectively. By contrast, haematogenous dissemination was apparently the result of absent functional wild-type p53 (whether or not the cell contained mutated p53). These results are of potential importance in the prediction of the clinical behaviour of a tumour.

引用

页码：233 / 234

页数：2

共 10 条

[1]

BARLOGIE B, 1983, CANCER RES, V43, P3982

[2]

CHANG FJ, 1993, AM J GASTROENTEROL, V88, P174

[3] PROGRESSING TOWARD A MOLECULAR DESCRIPTION OF COLORECTAL-CANCER DEVELOPMENT [J].