TGF-BETA-S AND TGF-BETA TYPE-II RECEPTOR IN HUMAN EPIDERMIS - DIFFERENTIAL EXPRESSION IN ACUTE AND CHRONIC SKIN WOUNDS

被引:115
作者
SCHMID, P
COX, D
BILBE, G
MCMASTER, G
MORRISON, C
STAHELIN, H
LUSCHER, N
SEILER, W
机构
[1] CIBA GEIGY AG, DIV PHARM, CH-4002 BASEL, SWITZERLAND
[2] CIBA GEIGY SA, DIV ANIM HLTH, CH-1566 ST AUBIN, SWITZERLAND
[3] UNIV HOSP BASEL, PLAST SURG CLIN, CH-4031 BASEL, SWITZERLAND
关键词
TRANSFORMING GROWTH FACTOR-BETA; TRANSFORMING GROWTH FACTOR-BETA TYPE-II RECEPTOR; IN-SITU HYBRIDIZATION; EPIDERMIS; DECUBITUS ULCERS; WOUND HEALING;
D O I
10.1002/path.1711710307
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Exogenously applied transforming growth factor-beta (TGF-beta) isoforms enhance wound healing processes in animal models;1 however, little is known about the expression of endogenous TGF-betas and TGF-beta receptors in intact human skin or during wound healing. The present study has revealed several unexpected findings by means of in situ hybridization and immunohistology techniques. In humans, TGF-beta3 is constitutively expressed in the epidermis of intact skin and in that of acute and chronic wounds-a pattern of expression closely mirrored by the TGF-beta type II receptor. Although not detected in intact skin, TGF-beta1 mRNA expression was observed in the regenerating epidermis of acute (thermal) wounds but was not found in chronic decubital (pressure) wounds. TGF-beta2 mRNA expression was not detected in the epidermis of any human skin or wound biopsies. From these findings we suggest that constitutive expression of TGF-beta3 is important for maintenance of epidermal differentiation and that an induction of TGF-beta1 expression is essential for re-epithelialization of human skin wounds. Lack of TGF-beta1 expression in chronic pressure wounds may be associated with their protracted healing tendencies.
引用
收藏
页码:191 / 197
页数:7
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